---
title: "TextGrad: Automatic \"Differentiation\" via Text (2024)"
description: "The authors propose TextGrad, a framework that treats such a pipeline as a… 91.9% accuracy. 104 references, cited by 76 papers here."
authors: ["Mert Yuksekgonul", "Federico Bianchi", "Joseph Boen", "Sheng Liu", "Zhi Huang", "Carlos Guestrin", "James Zou"]
year: 2024
venue: "arXiv:2406.07496"
source: "https://arxiv.org/abs/2406.07496"
doi: "10.48550/arxiv.2406.07496"
arxiv: "2406.07496"
licence: "CC BY 4.0 (arXiv)"
licence_url: "http://creativecommons.org/licenses/by/4.0/"
summary_licence: "Elamur Cosmic License"
canonical: "https://research.elamur.ai/free/en/papers/yuksekgonul-2024-textgrad-automatic-differentiation-text/"
---
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# TextGrad: Automatic "Differentiation" via Text

**Authors:** [Mert Yuksekgonul](https://md.research.elamur.ai/free/en/authors/mert-yuksekgonul/), [Federico Bianchi](https://md.research.elamur.ai/free/en/authors/federico-bianchi/), Joseph Boen, Sheng Liu, Zhi Huang, [Carlos Guestrin](https://md.research.elamur.ai/free/en/authors/carlos-guestrin/) and [James Zou](https://md.research.elamur.ai/free/en/authors/james-zou/) · **Year:** 2024 · **Venue:** arXiv:2406.07496 · **Licence:** [CC BY 4.0 (arXiv)](http://creativecommons.org/licenses/by/4.0/)

**Links:** [Publisher's page](https://arxiv.org/abs/2406.07496) · [PDF](https://arxiv.org/pdf/2406.07496) · [DOI 10.48550/arxiv.2406.07496](https://doi.org/10.48550/arxiv.2406.07496) · [arXiv 2406.07496](https://arxiv.org/abs/2406.07496) · [OpenAlex](https://openalex.org/W4399655920)

**Citations:** 12 citations (OpenAlex, 2026-10-14) · [76](https://md.research.elamur.ai/free/en/papers/yuksekgonul-2024-textgrad-automatic-differentiation-text/cited-by/) in our library, of the 141,840 papers whose bibliographies we read

## Summary
Modern AI applications increasingly chain several LLMs with tools such as simulators, solvers, or search engines. These compound pipelines are usually tuned by hand, and their parts are not differentiable, so standard gradient training does not apply. The authors propose TextGrad, a framework that treats such a pipeline as a computation graph and borrows the idea of backpropagation. Instead of numerical gradients, an LLM writes natural-language critiques ("textual gradients") explaining how each variable should change to improve a downstream objective. These critiques are passed backward through arbitrary function calls, and an optimizer then rewrites the variables. The API deliberately mirrors PyTorch. Users only define the objective, with no task-specific prompt tuning. Unlike earlier prompt-focused systems such as DSPy and ProTeGi, TextGrad also optimizes individual solutions directly, including code, answers, molecules, and treatment plans. Experiments cover coding, scientific question answering, prompt optimization for reasoning, drug-like molecule design, and radiotherapy planning. The work matters because it offers one general, open-source way to automatically improve multi-component LLM systems.

## Key points
- On Google-Proof Question Answering (GPQA), refining answers at test time lifts GPT-4o zero-shot accuracy from 51% to 55%.
- On LeetCode-Hard coding problems, TextGrad gives about a 20% relative gain over gpt-4o and the best prior method.
- Prompt optimization brings GPT-3.5 close to GPT-4 on several reasoning tasks; one illustrated prompt rises from 77.8% to 91.9% accuracy.
- PyTorch-style abstractions include `tg.Variable`, `tg.BlackboxLLM`, `tg.TextLoss`, and the `tg.TGD` optimizer, with `loss.backward()` and `optimizer.step()` calls.
- The molecule and prostate-cancer radiotherapy results are proof-of-concept, validated only in silico (e.g., Vina scores). The code is released at github.com/zou-group/textgrad.

*Our summary of the paper, in our own words — not its text. The work belongs to its authors; read it at the links above.*

## Institutions

- [Stanford University](https://md.research.elamur.ai/free/en/universities/stanford-university/) — University, Stanford, United States · 310 works · 284,480 citations

📚 Shelves (4): [🖥️ Computer Science](https://md.research.elamur.ai/free/en/shelves/computer-science/) · 9,086 works · [🤖 Artificial Intelligence](https://md.research.elamur.ai/free/en/shelves/computer-science/artificial-intelligence/) · 8,889 works · [🎭 Arts and Humanities](https://md.research.elamur.ai/free/en/shelves/arts-and-humanities/) · 9,296 works · [🗣️ Language and Linguistics](https://md.research.elamur.ai/free/en/shelves/arts-and-humanities/language-and-linguistics/) · 9,206 works

## Cite

Cite as: Mert Yuksekgonul, Federico Bianchi, Joseph Boen, Sheng Liu, Zhi Huang, Carlos Guestrin and James Zou. 2024. TextGrad: Automatic "Differentiation" via Text. arXiv:2406.07496.

The paper itself, not this page. BibTeX from the library's record of the work.

```bibtex
@misc{yuksekgonul2024textgrad,
  title = {{TextGrad: Automatic "Differentiation" via Text}},
  author = {Mert Yuksekgonul, Federico Bianchi, Joseph Boen, Sheng Liu, Zhi Huang, Carlos Guestrin and James Zou},
  year = {2024},
  doi = {10.48550/arxiv.2406.07496},
  eprint = {2406.07496},
  archivePrefix = {arXiv},
  url = {https://doi.org/10.48550/arxiv.2406.07496}
}
```

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## References

104 references, 33 of them with a card of ours. ↗ leads to the work, «find» searches for one we have no id for yet.

1. Brown, T., Mann, B., Ryder, N., Subbiah, M., Kaplan, J. D., Dhariwal, P., Neelakantan, A., Shyam, P., Sastry, G., Askell, A., et al. [Language models are few-shot learners](https://md.research.elamur.ai/free/en/papers/brown-2020-language-models-few-shot-learners/). Advances in neural information processing systems 33, 1877–1901 (2020).
2. Achiam, J., Adler, S., Agarwal, S., Ahmad, L., Akkaya, I., Aleman, F. L., Almeida, D., Altenschmidt, J., Altman, S., Anadkat, S., et al. [Gpt-4 technical report](https://md.research.elamur.ai/free/en/papers/openai-2023-gpt-4-technical-report/). arXiv preprint arXiv:2303.08774 (2023).
3. Reid, M., Savinov, N., Teplyashin, D., Lepikhin, D., Lillicrap, T., Alayrac, J.-b., Soricut, R., Lazaridou, A., Firat, O., Schrittwieser, J., et al. [Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context](https://md.research.elamur.ai/free/en/papers/gemini-team-2024-gemini-1-5-unlocking-multimodal/). arXiv preprint arXiv:2403.05530 (2024).
4. AI@Meta. Llama 3 Model Card. [https://github.com/meta-llama/llama3/blob/main/MODEL_](https://github.com/meta-llama/llama3/blob/main/MODEL_) CARD.md (2024). [↗](https://github.com/meta-llama/llama3/blob/main/MODEL_)
5. Anthropic, A. The Claude 3 Model Family: Opus, Sonnet, Haiku. Claude-3 Model Card (2024). [find](https://scholar.google.com/scholar?q=Anthropic%2C+A%2E+The+Claude+3+Model+Family%3A+Opus%2C+Sonnet%2C+Haiku%2E+Claude%2D3+Model+Card+%282024%29%2E)
6. Bommasani, R., Hudson, D. A., Adeli, E., Altman, R., Arora, S., von Arx, S., Bernstein, M. S., Bohg, J., Bosselut, A., Brunskill, E., et al. [On the opportunities and risks of foundation models](https://md.research.elamur.ai/free/en/papers/bommasani-2021-opportunities-risks-foundation-models/). arXiv preprint arXiv:2108.07258 (2021).
7. Trinh, T. H., Wu, Y., Le, Q. V., He, H. & Luong, T. [Solving olympiad geometry without human demonstrations](https://md.research.elamur.ai/free/en/papers/trinh-2024-solving-olympiad-geometry-without-human/). Nature 625, 476–482 (2024).
8. Li, Y., Choi, D., Chung, J., Kushman, N., Schrittwieser, J., Leblond, R., Eccles, T., Keeling, J., Gimeno, F., Dal Lago, A., et al. [Competition-level code generation with alphacode](https://md.research.elamur.ai/free/en/papers/li-2022-competition-level-code-generation-alphacode/). Science 378, 1092–1097 (2022).
9. Yang, J., Jimenez, C. E., Wettig, A., Lieret, K., Yao, S., Narasimhan, K. & Press, O. [SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering](https://md.research.elamur.ai/free/en/papers/yang-2024-swe-agent-agent-computer-interfaces/) 2024.
10. Khattab, O., Singhvi, A., Maheshwari, P., Zhang, Z., Santhanam, K., A, S. V., Haq, S., Sharma, A., Joshi, T. T., Moazam, H., Miller, H., Zaharia, M. & Potts, C. DSPy: Compiling Declarative Language Model Calls into State-of-the-Art Pipelines in The Twelfth International Conference on Learning Repres… [find](https://scholar.google.com/scholar?q=Khattab%2C+O%2E%2C+Singhvi%2C+A%2E%2C+Maheshwari%2C+P%2E%2C+Zhang%2C+Z%2E%2C+Santhanam%2C+K%2E%2C+A%2C+S%2E+V%2E%2C+Haq%2C+S%2E%2C+Sharma%2C+A%2E%2C+Joshi%2C+T%2E+T%2E%2C+Moazam%2C+H%2E%2C+Miller%2C+H%2E%2C+Zaharia%2C+M%2E+%26+Potts%2C+C%2E+DSPy%3A+Compiling+Declarative+Language+Mo)
11. Zaharia, M., Khattab, O., Chen, L., Davis, J. Q., Miller, H., Potts, C., Zou, J., Carbin, M., Frankle, J., Rao, N. & Ghodsi, A. The Shift from Models to Compound AI Systems [https://bair.berkeley.edu/](https://bair.berkeley.edu/) blog/2024/02/18/compound-ai-systems/. 2024. [↗](https://bair.berkeley.edu/)
12. Zhou, Y., Muresanu, A. I., Han, Z., Paster, K., Pitis, S., Chan, H. & Ba, J. [Large Language Models are Human-Level Prompt Engineers](https://md.research.elamur.ai/free/en/papers/zhou-2022-large-language-models-human-level/) in The Eleventh International Conference on Learning Representations (2023). [https://openreview.net/forum?id=92gvk82DE-](https://openreview.net/forum?id=92gvk82DE-). [↗](https://openreview.net/forum?id=92gvk82DE-)
13. Krizhevsky, A., Sutskever, I. & Hinton, G. E. Imagenet classification with deep convolutional neural networks. Advances in neural information processing systems 25 (2012). [find](https://scholar.google.com/scholar?q=Krizhevsky%2C+A%2E%2C+Sutskever%2C+I%2E+%26+Hinton%2C+G%2E+E%2E+Imagenet+classification+with+deep+convolutional+neural+networks%2E+Advances+in+neural+information+processing+systems+25+%282012%29%2E)
14. Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. [Highly accurate protein structure prediction with AlphaFold](https://md.research.elamur.ai/free/en/papers/jumper-2021-highly-accurate-protein-structure-prediction/). Nature 596, 583–589 (2021).
15. Fawzi, A., Balog, M., Huang, A., Hubert, T., Romera-Paredes, B., Barekatain, M., Novikov, A., R Ruiz, F. J., Schrittwieser, J., Swirszcz, G., et al. Discovering faster matrix multiplication algorithms with reinforcement learning. Nature 610, 47–53 (2022). [find](https://scholar.google.com/scholar?q=Fawzi%2C+A%2E%2C+Balog%2C+M%2E%2C+Huang%2C+A%2E%2C+Hubert%2C+T%2E%2C+Romera%2DParedes%2C+B%2E%2C+Barekatain%2C+M%2E%2C+Novikov%2C+A%2E%2C+R+Ruiz%2C+F%2E+J%2E%2C+Schrittwieser%2C+J%2E%2C+Swirszcz%2C+G%2E%2C+et+al%2E+Discovering+faster+matrix+multiplication+algorithms)
16. Mankowitz, D. J., Michi, A., Zhernov, A., Gelmi, M., Selvi, M., Paduraru, C., Leurent, E., Iqbal, S., Lespiau, J.-B., Ahern, A., et al. Faster sorting algorithms discovered using deep reinforcement learning. Nature 618, 257–263 (2023). [find](https://scholar.google.com/scholar?q=Mankowitz%2C+D%2E+J%2E%2C+Michi%2C+A%2E%2C+Zhernov%2C+A%2E%2C+Gelmi%2C+M%2E%2C+Selvi%2C+M%2E%2C+Paduraru%2C+C%2E%2C+Leurent%2C+E%2E%2C+Iqbal%2C+S%2E%2C+Lespiau%2C+J%2E%2DB%2E%2C+Ahern%2C+A%2E%2C+et+al%2E+Faster+sorting+algorithms+discovered+using+deep+reinforcement+le)
17. Merchant, A., Batzner, S., Schoenholz, S. S., Aykol, M., Cheon, G. & Cubuk, E. D. Scaling deep learning for materials discovery. Nature 624, 80–85 (2023). [find](https://scholar.google.com/scholar?q=Merchant%2C+A%2E%2C+Batzner%2C+S%2E%2C+Schoenholz%2C+S%2E+S%2E%2C+Aykol%2C+M%2E%2C+Cheon%2C+G%2E+%26+Cubuk%2C+E%2E+D%2E+Scaling+deep+learning+for+materials+discovery%2E+Nature+624%2C+80%E2%80%9385+%282023%29%2E)
18. Goodfellow, I., Bengio, Y. & Courville, A. Deep learning (MIT press, 2016). [find](https://scholar.google.com/scholar?q=Goodfellow%2C+I%2E%2C+Bengio%2C+Y%2E+%26+Courville%2C+A%2E+Deep+learning+%28MIT+press%2C+2016%29%2E)
19. Rumelhart, D. E., Hinton, G. E. & Williams, R. J. Learning representations by back-propagating errors. Nature 323, 533–536 (1986). Jia, Y., Shelhamer, E., Donahue, J., Karayev, S., Long, J., Girshick, R., Guadarrama, S. & Darrell, T. [Caffe: Convolutional Architecture for Fast Feature Embedding](https://md.research.elamur.ai/free/en/papers/jia-2014-caffe-convolutional-architecture-fast-feature/). arXi…
20. Bergstra, J., Breuleux, O., Bastien, F., Lamblin, P., Pascanu, R., Desjardins, G., Turian, J., Warde-Farley, D. & Bengio, Y. Theano: A CPU and GPU Math Expression Compiler in Proceedings of the Python for Scientific Computing Conference (SciPy) (2010). [find](https://scholar.google.com/scholar?q=Bergstra%2C+J%2E%2C+Breuleux%2C+O%2E%2C+Bastien%2C+F%2E%2C+Lamblin%2C+P%2E%2C+Pascanu%2C+R%2E%2C+Desjardins%2C+G%2E%2C+Turian%2C+J%2E%2C+Warde%2DFarley%2C+D%2E+%26+Bengio%2C+Y%2E+Theano%3A+A+CPU+and+GPU+Math+Expression+Compiler+in+Proceedings+of+the+Python)
21. Abadi, M., Barham, P., Chen, J., Chen, Z., Davis, A., Dean, J., Devin, M., Ghemawat, S., Irving, G., Isard, M., et al. TensorFlow: A System for Large-Scale Machine Learning in 12th USENIX Symposium on Operating Systems Design and Implementation (OSDI 16) (2016), 265–283. [find](https://scholar.google.com/scholar?q=Abadi%2C+M%2E%2C+Barham%2C+P%2E%2C+Chen%2C+J%2E%2C+Chen%2C+Z%2E%2C+Davis%2C+A%2E%2C+Dean%2C+J%2E%2C+Devin%2C+M%2E%2C+Ghemawat%2C+S%2E%2C+Irving%2C+G%2E%2C+Isard%2C+M%2E%2C+et+al%2E+TensorFlow%3A+A+System+for+Large%2DScale+Machine+Learning+in+12th+USENIX+Symposium+on)
22. Paszke, A., Gross, S., Massa, F., Lerer, A., Bradbury, J., Chanan, G., Killeen, T., Lin, Z., Gimelshein, N., Antiga, L., et al. [Pytorch: An imperative style, high-performance deep learning library](https://md.research.elamur.ai/free/en/papers/paszke-2019-pytorch-imperative-style-high-performance/). Advances in neural information processing systems 32 (2019).
23. Collobert, R., Bengio, S. & Mariéthoz, J. Torch: a modular machine learning software library (2002). [find](https://scholar.google.com/scholar?q=Collobert%2C+R%2E%2C+Bengio%2C+S%2E+%26+Mari%C3%A9thoz%2C+J%2E+Torch%3A+a+modular+machine+learning+software+library+%282002%29%2E)
24. Pryzant, R., Iter, D., Li, J., Lee, Y., Zhu, C. & Zeng, M. Automatic Prompt Optimization with “Gradient Descent” and Beam Search in Proceedings of the 2023 [Conference on Empirical Methods in Natural Language Processing (eds Bouamor, H., Pino, J](https://md.research.elamur.ai/free/en/papers/pryzant-2023-automatic-prompt-optimization-gradient-descent/). & Bali, K.) (Association for Computational Linguistics…
25. Shinn, N., Cassano, F., Gopinath, A., Narasimhan, K. & Yao, S. [Reflexion: language agents with verbal reinforcement learning](https://md.research.elamur.ai/free/en/papers/shinn-2023-reflexion-language-agents-verbal-reinforcement/) in Advances in Neural Information Processing Systems 36 (2023). [https://proceedings.neurips.cc/paper_files/paper/2023/file/1b44b878bb782e6954cd888628510e90-Paper-Conferenc…](https://proceedings.neurips.cc/paper_files/paper/2023/file/1b44b878bb782e6954cd888628510e90-Paper-Conferenc…) [↗](https://proceedings.neurips.cc/paper_files/paper/2023/file/1b44b878bb782e6954cd888628510e90-Paper-Conferenc…)
26. Rein, D., Hou, B. L., Stickland, A. C., Petty, J., Pang, R. Y., Dirani, J., Michael, J. & Bowman, S. R. [Gpqa: A graduate-level google-proof q&a benchmark](https://md.research.elamur.ai/free/en/papers/rein-2023-gpqa-graduate-level-google-proof/). arXiv preprint arXiv:2311.12022 (2023).
27. Li, X., Zhang, T., Dubois, Y., Taori, R., Gulrajani, I., Guestrin, C., Liang, P. & Hashimoto, T. B. Alpacaeval: An automatic evaluator of instruction-following models 2023. [find](https://scholar.google.com/scholar?q=Li%2C+X%2E%2C+Zhang%2C+T%2E%2C+Dubois%2C+Y%2E%2C+Taori%2C+R%2E%2C+Gulrajani%2C+I%2E%2C+Guestrin%2C+C%2E%2C+Liang%2C+P%2E+%26+Hashimoto%2C+T%2E+B%2E+Alpacaeval%3A+An+automatic+evaluator+of+instruction%2Dfollowing+models+2023%2E)
28. Bai, Y., Jones, A., Ndousse, K., Askell, A., Chen, A., DasSarma, N., Drain, D., Fort, S., Ganguli, D., Henighan, T., et al. Training a helpful and harmless assistant with reinforcement learning from human feedback. arXiv preprint arXiv:2204.05862 (2022). [find](https://scholar.google.com/scholar?q=Bai%2C+Y%2E%2C+Jones%2C+A%2E%2C+Ndousse%2C+K%2E%2C+Askell%2C+A%2E%2C+Chen%2C+A%2E%2C+DasSarma%2C+N%2E%2C+Drain%2C+D%2E%2C+Fort%2C+S%2E%2C+Ganguli%2C+D%2E%2C+Henighan%2C+T%2E%2C+et+al%2E+Training+a+helpful+and+harmless+assistant+with+reinforcement+learning+from+h)
29. Madaan, A., Tandon, N., Gupta, P., Hallinan, S., Gao, L., Wiegreffe, S., Alon, U., Dziri, N., Prabhumoye, S., Yang, Y., et al. Self-refine: Iterative refinement with self-feedback. Advances in Neural Information Processing Systems 36 (2024). [find](https://scholar.google.com/scholar?q=Madaan%2C+A%2E%2C+Tandon%2C+N%2E%2C+Gupta%2C+P%2E%2C+Hallinan%2C+S%2E%2C+Gao%2C+L%2E%2C+Wiegreffe%2C+S%2E%2C+Alon%2C+U%2E%2C+Dziri%2C+N%2E%2C+Prabhumoye%2C+S%2E%2C+Yang%2C+Y%2E%2C+et+al%2E+Self%2Drefine%3A+Iterative+refinement+with+self%2Dfeedback%2E+Advances+in+Neural+)
30. Stiennon, N., Ouyang, L., Wu, J., Ziegler, D., Lowe, R., Voss, C., Radford, A., Amodei, D. & Christiano, P. F. Learning to summarize with human feedback. Advances in Neural Information Processing Systems 33, 3008–3021 (2020). [find](https://scholar.google.com/scholar?q=Stiennon%2C+N%2E%2C+Ouyang%2C+L%2E%2C+Wu%2C+J%2E%2C+Ziegler%2C+D%2E%2C+Lowe%2C+R%2E%2C+Voss%2C+C%2E%2C+Radford%2C+A%2E%2C+Amodei%2C+D%2E+%26+Christiano%2C+P%2E+F%2E+Learning+to+summarize+with+human+feedback%2E+Advances+in+Neural+Information+Processing+Syst)
31. Yuan, W., Pang, R. Y., Cho, K., Sukhbaatar, S., Xu, J. & Weston, J. Self-rewarding language models. arXiv preprint arXiv:2401.10020 (2024). [find](https://scholar.google.com/scholar?q=Yuan%2C+W%2E%2C+Pang%2C+R%2E+Y%2E%2C+Cho%2C+K%2E%2C+Sukhbaatar%2C+S%2E%2C+Xu%2C+J%2E+%26+Weston%2C+J%2E+Self%2Drewarding+language+models%2E+arXiv+preprint+arXiv%3A2401%2E10020+%282024%29%2E)
32. Dubois, Y., Li, C. X., Taori, R., Zhang, T., Gulrajani, I., Ba, J., Guestrin, C., Liang, P. S. & Hashimoto, T. B. [Alpacafarm: A simulation framework for methods that learn from human feedback](https://md.research.elamur.ai/free/en/papers/dubois-2023-alpacafarm-simulation-framework-methods-that/). Advances in Neural Information Processing Systems 36 (2024).
33. Bottou, L. Large-scale machine learning with stochastic gradient descent. Proceedings of COMPSTAT’2010, 177–186 (2010). [find](https://scholar.google.com/scholar?q=Bottou%2C+L%2E+Large%2Dscale+machine+learning+with+stochastic+gradient+descent%2E+Proceedings+of+COMPSTAT%E2%80%992010%2C+177%E2%80%93186+%282010%29%2E)
34. Boyd, S., Boyd, S. P. & Vandenberghe, L. Convex optimization (Cambridge university press, 2004). [find](https://scholar.google.com/scholar?q=Boyd%2C+S%2E%2C+Boyd%2C+S%2E+P%2E+%26+Vandenberghe%2C+L%2E+Convex+optimization+%28Cambridge+university+press%2C+2004%29%2E)
35. Ouyang, L., Wu, J., Jiang, X., Almeida, D., Wainwright, C., Mishkin, P., Zhang, C., Agarwal, S., Slama, K., Ray, A., et al. [Training language models to follow instructions with human feedback](https://md.research.elamur.ai/free/en/papers/ouyang-2022-training-language-models-follow-instructions/). Advances in neural information processing systems 35, 27730–27744 (2022).
36. Wei, J., Bosma, M., Zhao, V., Guu, K., Yu, A. W., Lester, B., Du, N., Dai, A. M. & Le, Q. V. Finetuned Language Models are Zero-Shot Learners in International Conference on Learning Representations (2022). [https://openreview.net/forum?id=gEZrGCozdqR](https://openreview.net/forum?id=gEZrGCozdqR). Yuksekgonul, M., Chandrasekaran, V., Jones, E., G… [↗](https://openreview.net/forum?id=gEZrGCozdqR)
37. Abdin, M. I., Gunasekar, S., Chandrasekaran, V., Li, J., Yuksekgonul, M., Peshawaria, R. G., Naik, R. & Nushi, B. KITAB: Evaluating LLMs on Constraint Satisfaction for Information Retrieval in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net](https://openreview.net) / for… [↗](https://openreview.net)
38. Polyak, B. T. Some methods of speeding up the convergence of iteration methods. USSR Computational Mathematics and Mathematical Physics 4, 1–17 (1964). [find](https://scholar.google.com/scholar?q=Polyak%2C+B%2E+T%2E+Some+methods+of+speeding+up+the+convergence+of+iteration+methods%2E+USSR+Computational+Mathematics+and+Mathematical+Physics+4%2C+1%E2%80%9317+%281964%29%2E)
39. Sutskever, I., Martens, J., Dahl, G. & Hinton, G. On the importance of initialization and momentum in deep learning in International conference on machine learning (2013), 1139–1147. [find](https://scholar.google.com/scholar?q=Sutskever%2C+I%2E%2C+Martens%2C+J%2E%2C+Dahl%2C+G%2E+%26+Hinton%2C+G%2E+On+the+importance+of+initialization+and+momentum+in+deep+learning+in+International+conference+on+machine+learning+%282013%29%2C+1139%E2%80%931147%2E)
40. Sun, Y., Wang, X., Liu, Z., Miller, J., Efros, A. & Hardt, M. Test-Time Training with Self-Supervision for Generalization under Distribution Shifts in Proceedings of the 37th International Conference on Machine Learning (PMLR, 2020). [https://proceedings.mlr.press/v119/sun20b.html](https://proceedings.mlr.press/v119/sun20b.html). [↗](https://proceedings.mlr.press/v119/sun20b.html)
41. Sun, Y., Li, X., Dalal, K., Hsu, C., Koyejo, S., Guestrin, C., Wang, X., Hashimoto, T. & Chen, X. Learning to (learn at test time). arXiv preprint arXiv:2310.13807 (2023). [find](https://scholar.google.com/scholar?q=Sun%2C+Y%2E%2C+Li%2C+X%2E%2C+Dalal%2C+K%2E%2C+Hsu%2C+C%2E%2C+Koyejo%2C+S%2E%2C+Guestrin%2C+C%2E%2C+Wang%2C+X%2E%2C+Hashimoto%2C+T%2E+%26+Chen%2C+X%2E+Learning+to+%28learn+at+test+time%29%2E+arXiv+preprint+arXiv%3A2310%2E13807+%282023%29%2E)
42. Yao, S., Zhao, J., Yu, D., Du, N., Shafran, I., Narasimhan, K. R. & Cao, Y. [ReAct: Synergizing Reasoning and Acting in Language Models](https://md.research.elamur.ai/free/en/papers/yao-2022-react-synergizing-reasoning-acting-language/) in The Eleventh International Conference on Learning Representations (2023). [https://openreview.net/forum?id=WE_vluYUL-X](https://openreview.net/forum?id=WE_vluYUL-X). [↗](https://openreview.net/forum?id=WE_vluYUL-X)
43. Hendrycks, D., Burns, C., Basart, S., Zou, A., Mazeika, M., Song, D. & Steinhardt, J. [Measuring Massive Multitask Language Understanding](https://md.research.elamur.ai/free/en/papers/hendrycks-2020-measuring-massive-multitask-language-understanding/) in International Conference on Learning Representations (2021). [https://openreview.net/forum?id=d7KBjmI3GmQ](https://openreview.net/forum?id=d7KBjmI3GmQ). [↗](https://openreview.net/forum?id=d7KBjmI3GmQ)
44. Kojima, T., Gu, S. S., Reid, M., Matsuo, Y. & Iwasawa, Y. [Large language models are zero-shot reasoners](https://md.research.elamur.ai/free/en/papers/kojima-2022-large-language-models-zero-shot/). Advances in neural information processing systems 35, 22199–22213 (2022).
45. Wei, J., Wang, X., Schuurmans, D., Bosma, M., Xia, F., Chi, E., Le, Q. V., Zhou, D., et al. [Chain-of-thought prompting elicits reasoning in large language models](https://md.research.elamur.ai/free/en/papers/wei-2022-chain-thought-prompting-elicits-reasoning/). Advances in neural information processing systems 35, 24824–24837 (2022).
46. OpenAI. Hello GPT-4o Accessed: 2024-05-18. 2024. [https://openai.com/index/hello-gpt-4o/](https://openai.com/index/hello-gpt-4o/). [↗](https://openai.com/index/hello-gpt-4o/)
47. Liu, P., Yuan, W., Fu, J., Jiang, Z., Hayashi, H. & Neubig, G. [Pre-train, prompt, and predict: A systematic survey of prompting methods in natural language processing](https://md.research.elamur.ai/free/en/papers/liu-2021-pre-train-prompt-predict-systematic/). ACM Computing Surveys 55, 1–35 (2023).
48. Suzgun, M., Scales, N., Schärli, N., Gehrmann, S., Tay, Y., Chung, H. W., Chowdhery, A., Le, Q., Chi, E., Zhou, D. & Wei, J. [Challenging BIG-Bench Tasks and Whether Chain-of-Thought Can Solve Them](https://md.research.elamur.ai/free/en/papers/suzgun-2023-challenging-big-bench-tasks-whether/) in Findings of the Association for Computational Linguistics: ACL 2023 (Association for Computational L…
49. Srivastava, A. et al. [Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models](https://md.research.elamur.ai/free/en/papers/srivastava-2022-imitation-game-quantifying-extrapolating-capabilities/). Transactions on Machine Learning Research. ISSN : 2835-8856. [https://openreview.net/forum?id=uyTL5Bvosj](https://openreview.net/forum?id=uyTL5Bvosj) (2023). [↗](https://openreview.net/forum?id=uyTL5Bvosj)
50. Cobbe, K., Kosaraju, V., Bavarian, M., Chen, M., Jun, H., Kaiser, L., Plappert, M., Tworek, J., Hilton, J., Nakano, R., Hesse, C. & Schulman, J. [Training Verifiers to Solve Math Word Problems](https://md.research.elamur.ai/free/en/papers/cobbe-2021-training-verifiers-solve-math-word/). arXiv preprint arXiv:2110.14168 (2021).
51. Nicolaou, C. A. & Brown, N. Multi-objective optimization methods in drug design. Drug Discovery Today: Technologies 10, e427–e435 (2013). [find](https://scholar.google.com/scholar?q=Nicolaou%2C+C%2E+A%2E+%26+Brown%2C+N%2E+Multi%2Dobjective+optimization+methods+in+drug+design%2E+Drug+Discovery+Today%3A+Technologies+10%2C+e427%E2%80%93e435+%282013%29%2E)
52. Hoelder, S., Clarke, P. A. & Workman, P. Discovery of small molecule cancer drugs: successes, challenges and opportunities. Molecular oncology 6, 155–176 (2012). [find](https://scholar.google.com/scholar?q=Hoelder%2C+S%2E%2C+Clarke%2C+P%2E+A%2E+%26+Workman%2C+P%2E+Discovery+of+small+molecule+cancer+drugs%3A+successes%2C+challenges+and+opportunities%2E+Molecular+oncology+6%2C+155%E2%80%93176+%282012%29%2E)
53. Kontoyianni, M. Docking and virtual screening in drug discovery. Proteomics for drug discovery: Methods and protocols, 255–266 (2017). Agarwal, S. & Mehrotra, R. An overview of molecular docking. JSM chem 4, 1024–1028 (2016). [find](https://scholar.google.com/scholar?q=Kontoyianni%2C+M%2E+Docking+and+virtual+screening+in+drug+discovery%2E+Proteomics+for+drug+discovery%3A+Methods+and+protocols%2C+255%E2%80%93266+%282017%29%2E+Agarwal%2C+S%2E+%26+Mehrotra%2C+R%2E+An+overview+of+molecular+docking%2E+JSM+)
54. Trott, O. & Olson, A. J. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of computational chemistry 31, 455– 461 (2010). [find](https://scholar.google.com/scholar?q=Trott%2C+O%2E+%26+Olson%2C+A%2E+J%2E+AutoDock+Vina%3A+improving+the+speed+and+accuracy+of+docking+with+a+new+scoring+function%2C+efficient+optimization%2C+and+multithreading%2E+Journal+of+computational+chemistry+31%2C+455%E2%80%93)
55. Ursu, O., Rayan, A., Goldblum, A. & Oprea, T. I. Understanding drug-likeness. Wiley Interdisciplinary Reviews: Computational Molecular Science 1, 760–781 (2011). [find](https://scholar.google.com/scholar?q=Ursu%2C+O%2E%2C+Rayan%2C+A%2E%2C+Goldblum%2C+A%2E+%26+Oprea%2C+T%2E+I%2E+Understanding+drug%2Dlikeness%2E+Wiley+Interdisciplinary+Reviews%3A+Computational+Molecular+Science+1%2C+760%E2%80%93781+%282011%29%2E)
56. Bickerton, G. R., Paolini, G. V., Besnard, J., Muresan, S. & Hopkins, A. L. Quantifying the chemical beauty of drugs. Nature chemistry 4, 90–98 (2012). [find](https://scholar.google.com/scholar?q=Bickerton%2C+G%2E+R%2E%2C+Paolini%2C+G%2E+V%2E%2C+Besnard%2C+J%2E%2C+Muresan%2C+S%2E+%26+Hopkins%2C+A%2E+L%2E+Quantifying+the+chemical+beauty+of+drugs%2E+Nature+chemistry+4%2C+90%E2%80%9398+%282012%29%2E)
57. Bender, B. J., Gahbauer, S., Luttens, A., Lyu, J., Webb, C. M., Stein, R. M., Fink, E. A., Balius, T. E., Carlsson, J., Irwin, J. J., et al. A practical guide to large-scale docking. Nature protocols 16, 4799–4832 (2021). [find](https://scholar.google.com/scholar?q=Bender%2C+B%2E+J%2E%2C+Gahbauer%2C+S%2E%2C+Luttens%2C+A%2E%2C+Lyu%2C+J%2E%2C+Webb%2C+C%2E+M%2E%2C+Stein%2C+R%2E+M%2E%2C+Fink%2C+E%2E+A%2E%2C+Balius%2C+T%2E+E%2E%2C+Carlsson%2C+J%2E%2C+Irwin%2C+J%2E+J%2E%2C+et+al%2E+A+practical+guide+to+large%2Dscale+docking%2E+Nature+protocols+)
58. García-Ortegón, M., Simm, G. N., Tripp, A. J., Hernández-Lobato, J. M., Bender, A. & Bacallado, S. DOCKSTRING: easy molecular docking yields better benchmarks for ligand design. Journal of chemical information and modeling 62, 3486–3502 (2022). [find](https://scholar.google.com/scholar?q=Garc%C3%ADa%2DOrteg%C3%B3n%2C+M%2E%2C+Simm%2C+G%2E+N%2E%2C+Tripp%2C+A%2E+J%2E%2C+Hern%C3%A1ndez%2DLobato%2C+J%2E+M%2E%2C+Bender%2C+A%2E+%26+Bacallado%2C+S%2E+DOCKSTRING%3A+easy+molecular+docking+yields+better+benchmarks+for+ligand+design%2E+Journal+of+chemical+in)
59. Khan, F. M., Sperduto, P. W. & Gibbons, J. P. Khan’s Treatment Planning in Radiation Oncology:. (Lippincott Williams & Wilkins, 2021). [find](https://scholar.google.com/scholar?q=Khan%2C+F%2E+M%2E%2C+Sperduto%2C+P%2E+W%2E+%26+Gibbons%2C+J%2E+P%2E+Khan%E2%80%99s+Treatment+Planning+in+Radiation+Oncology%3A%2E+%28Lippincott+Williams+%26+Wilkins%2C+2021%29%2E)
60. Webb, S. The physical basis of IMRT and inverse planning. The British journal of radiology 76, 678–689 (2003). [find](https://scholar.google.com/scholar?q=Webb%2C+S%2E+The+physical+basis+of+IMRT+and+inverse+planning%2E+The+British+journal+of+radiology+76%2C+678%E2%80%93689+%282003%29%2E)
61. Hussein, M., Heijmen, B. J. M., Verellen, D. & Nisbet, A. Automation in Intensity Modulated Radiotherapy Treatment Planning—a Review of Recent Innovations. British Journal of Radiology 91, 20180270. ISSN : 0007-1285. (2024) (Dec. 2018). [find](https://scholar.google.com/scholar?q=Hussein%2C+M%2E%2C+Heijmen%2C+B%2E+J%2E+M%2E%2C+Verellen%2C+D%2E+%26+Nisbet%2C+A%2E+Automation+in+Intensity+Modulated+Radiotherapy+Treatment+Planning%E2%80%94a+Review+of+Recent+Innovations%2E+British+Journal+of+Radiology+91%2C+20180270%2E+I)
62. Wieser, H.-P., Cisternas, E., Wahl, N., Ulrich, S., Stadler, A., Mescher, H., Müller, L.-R., Klinge, T., Gabrys, H., Burigo, L., et al. Development of the open-source dose calculation and optimization toolkit matRad. Medical Physics 44, 2556–2568 (2017). [find](https://scholar.google.com/scholar?q=Wieser%2C+H%2E%2DP%2E%2C+Cisternas%2C+E%2E%2C+Wahl%2C+N%2E%2C+Ulrich%2C+S%2E%2C+Stadler%2C+A%2E%2C+Mescher%2C+H%2E%2C+M%C3%BCller%2C+L%2E%2DR%2E%2C+Klinge%2C+T%2E%2C+Gabrys%2C+H%2E%2C+Burigo%2C+L%2E%2C+et+al%2E+Development+of+the+open%2Dsource+dose+calculation+and+optimization)
63. Nori, H., Lee, Y. T., Zhang, S., Carignan, D., Edgar, R., Fusi, N., King, N., Larson, J., Li, Y., Liu, W., et al. Can generalist foundation models outcompete special-purpose tuning? case study in medicine. arXiv preprint arXiv:2311.16452 (2023). [find](https://scholar.google.com/scholar?q=Nori%2C+H%2E%2C+Lee%2C+Y%2E+T%2E%2C+Zhang%2C+S%2E%2C+Carignan%2C+D%2E%2C+Edgar%2C+R%2E%2C+Fusi%2C+N%2E%2C+King%2C+N%2E%2C+Larson%2C+J%2E%2C+Li%2C+Y%2E%2C+Liu%2C+W%2E%2C+et+al%2E+Can+generalist+foundation+models+outcompete+special%2Dpurpose+tuning%3F+case+study+in+medi)
64. Shin, T., Razeghi, Y., Logan IV, R. L., Wallace, E. & Singh, S. [AutoPrompt: Eliciting Knowledge from Language Models with Automatically Generated Prompts](https://md.research.elamur.ai/free/en/papers/shin-2020-autoprompt-eliciting-knowledge-language-models/) in Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP) (Association for Computational Linguistics, Onli…
65. Jia, M., Tang, L., Chen, B.-C., Cardie, C., Belongie, S., Hariharan, B. & Lim, S.-N. Visual prompt tuning in European Conference on Computer Vision (2022), 709–727. [find](https://scholar.google.com/scholar?q=Jia%2C+M%2E%2C+Tang%2C+L%2E%2C+Chen%2C+B%2E%2DC%2E%2C+Cardie%2C+C%2E%2C+Belongie%2C+S%2E%2C+Hariharan%2C+B%2E+%26+Lim%2C+S%2E%2DN%2E+Visual+prompt+tuning+in+European+Conference+on+Computer+Vision+%282022%29%2C+709%E2%80%93727%2E)
66. Li, X. L. & Liang, P. Prefix-Tuning: Optimizing Continuous Prompts for Generation in Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing (Volume 1: Long Papers) (Association for Computation… [find](https://scholar.google.com/scholar?q=Li%2C+X%2E+L%2E+%26+Liang%2C+P%2E+Prefix%2DTuning%3A+Optimizing+Continuous+Prompts+for+Generation+in+Proceedings+of+the+59th+Annual+Meeting+of+the+Association+for+Computational+Linguistics+and+the+11th+International+)
67. Chen, X., Zhang, N., Xie, X., Deng, S., Yao, Y., Tan, C., Huang, F., Si, L. & Chen, H. Knowprompt: Knowledge-aware prompt-tuning with synergistic optimization for relation extraction in Proceedings of the ACM Web conference 2022 (2022), 2778–2788. [find](https://scholar.google.com/scholar?q=Chen%2C+X%2E%2C+Zhang%2C+N%2E%2C+Xie%2C+X%2E%2C+Deng%2C+S%2E%2C+Yao%2C+Y%2E%2C+Tan%2C+C%2E%2C+Huang%2C+F%2E%2C+Si%2C+L%2E+%26+Chen%2C+H%2E+Knowprompt%3A+Knowledge%2Daware+prompt%2Dtuning+with+synergistic+optimization+for+relation+extraction+in+Proceedings+of)
68. Ye, Q., Axmed, M., Pryzant, R. & Khani, F. Prompt engineering a prompt engineer. arXiv preprint arXiv:2311.05661 (2023). [find](https://scholar.google.com/scholar?q=Ye%2C+Q%2E%2C+Axmed%2C+M%2E%2C+Pryzant%2C+R%2E+%26+Khani%2C+F%2E+Prompt+engineering+a+prompt+engineer%2E+arXiv+preprint+arXiv%3A2311%2E05661+%282023%29%2E)
69. Khattab, O., Santhanam, K., Li, X. L., Hall, D., Liang, P., Potts, C. & Zaharia, M. [Demonstrate-Search-Predict: Composing Retrieval and Language Models for Knowledge-Intensive NLP](https://md.research.elamur.ai/free/en/papers/khattab-2022-demonstrate-search-predict-composing-retrieval/). arXiv preprint arXiv:2212.14024 (2022).
70. Singhvi, A., Shetty, M., Tan, S., Potts, C., Sen, K., Zaharia, M. & Khattab, O. DSPy Assertions: Computational Constraints for Self-Refining Language Model Pipelines. arXiv preprint arXiv:2312.[13382 (2023)](https://md.research.elamur.ai/free/en/papers/yang-2023-large-language-models-optimizers/). Yang, C., Wang, X., Lu, Y., Liu, H., Le, Q. V., Zhou, D. & Chen, X. Large Language Models as…
71. Song, X., Tian, Y., Lange, R. T., Lee, C., Tang, Y. & Chen, Y. Position: Leverage Foundational Models for Black-Box Optimization 2024. arXiv: 2405.03547 [cs.LG]. — [arXiv:2405.03547](https://arxiv.org/abs/2405.03547) [find](https://scholar.google.com/scholar?q=Song%2C+X%2E%2C+Tian%2C+Y%2E%2C+Lange%2C+R%2E+T%2E%2C+Lee%2C+C%2E%2C+Tang%2C+Y%2E+%26+Chen%2C+Y%2E+Position%3A+Leverage+Foundational+Models+for+Black%2DBox+Optimization+2024%2E+arXiv%3A+2405%2E03547+%5Bcs%2ELG%5D%2E+%E2%80%94+%5BarXiv%3A2405%2E03547%5D%28https%3A%2F%2Farxiv%2Eorg)
72. Liu, T., Astorga, N., Seedat, N. & van der Schaar, M. Large Language Models to Enhance Bayesian Optimization in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net/forum?id=OOxotBmGol](https://openreview.net/forum?id=OOxotBmGol). [↗](https://openreview.net/forum?id=OOxotBmGol)
73. Wang, R., Zelikman, E., Poesia, G., Pu, Y., Haber, N. & Goodman, N. Hypothesis Search: Inductive Reasoning with Language Models in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net/forum?id=G7UtIGQmjm](https://openreview.net/forum?id=G7UtIGQmjm). [↗](https://openreview.net/forum?id=G7UtIGQmjm)
74. Gao, L., Dai, Z., Pasupat, P., Chen, A., Chaganty, A. T., Fan, Y., Zhao, V., Lao, N., Lee, H., Juan, D.-C. & Guu, K. [RARR: Researching and Revising What Language Models Say, Using Language Models](https://md.research.elamur.ai/free/en/papers/gao-2023-rarr-researching-revising-what-language/) in Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Lo…
75. Chen, X., Lin, M., Schärli, N. & Zhou, D. Teaching Large Language Models to Self-Debug in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net/forum](https://openreview.net/forum) ? id = KuPixIqPiq. [↗](https://openreview.net/forum)
76. Shypula, A. G., Madaan, A., Zeng, Y., Alon, U., Gardner, J. R., Yang, Y., Hashemi, M., Neubig, G., Ranganathan, P., Bastani, O. & Yazdanbakhsh, A. Learning Performance-Improving Code Edits in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net/forum?](https://openreview.net/forum?) id=ix… [↗](https://openreview.net/forum?)
77. Chase, H. LangChain Oct. 17, 2022. [https://github.com/langchain-ai/langchain](https://github.com/langchain-ai/langchain). [↗](https://github.com/langchain-ai/langchain)
78. Liu, J. LlamaIndex [https://github.com/jerryjliu/llamaindex](https://github.com/jerryjliu/llamaindex). 2022. [↗](https://github.com/jerryjliu/llamaindex)
79. Schick, T., Dwivedi-Yu, J., Dessì, R., Raileanu, R., Lomeli, M., Hambro, E., Zettlemoyer, L., Cancedda, N. & Scialom, T. [Toolformer: Language models can teach themselves to use tools](https://md.research.elamur.ai/free/en/papers/schick-2023-toolformer-language-models-can-teach/). Advances in Neural Information Processing Systems 36 (2024).
80. Press, O., Zhang, M., Min, S., Schmidt, L., Smith, N. & Lewis, M. Measuring and Narrowing the Compositionality Gap in Language Models in Findings of the Association for Computational Linguistics: EMNLP 2023 (Association for Computational Linguistics, Singapore, Dec. 2023), 5687–5711. https://aclanth… [find](https://scholar.google.com/scholar?q=Press%2C+O%2E%2C+Zhang%2C+M%2E%2C+Min%2C+S%2E%2C+Schmidt%2C+L%2E%2C+Smith%2C+N%2E+%26+Lewis%2C+M%2E+Measuring+and+Narrowing+the+Compositionality+Gap+in+Language+Models+in+Findings+of+the+Association+for+Computational+Linguistics%3A+EMNL)
81. Zelikman, E., Wu, Y., Mu, J. & Goodman, N. [STaR: Bootstrapping Reasoning With Reasoning](https://md.research.elamur.ai/free/en/papers/zelikman-2022-star-bootstrapping-reasoning-reasoning/) in Advances in Neural Information Processing Systems (eds Koyejo, S., Mohamed, S., Agarwal, A., Belgrave, D., Cho, K. & Oh, A.) 35 (Curran Associates, Inc., 2022), 15476–15488. [https://proceedings.neurips.cc/](https://proceedings.neurips.cc/) pap… [↗](https://proceedings.neurips.cc/)
82. Huang, J., Gu, S., Hou, L., Wu, Y., Wang, X., Yu, H. & Han, J. [Large Language Models Can Self-Improve](https://md.research.elamur.ai/free/en/papers/huang-2023-large-language-models-can-self/) in Proceedings of the 2023 Conference on Empirical Methods in Natural Language Processing (eds Bouamor, H., Pino, J. & Bali, K.) (Association for Computational Linguistics, Singapore, Dec. 2023). ht…
83. Yang, K., Tian, Y., Peng, N. & Klein, D. Re3: Generating Longer Stories With Recursive Reprompting and Revision in Proceedings of the 2022 Conference on Empirical Methods in Natural Language Processing (Association for Computational Linguistics, Dec. 2022). https://aclanthology.org/2022 . em… [↗](https://aclanthology.org/2022)
84. [Xie, Y., Kawaguchi, K., Zhao, Y., Zhao, X., Kan, M.-Y., He, J. & Xie, Q. Self-Evaluation Guided Beam Search for Reasoning in Thirty-seventh Conference on Neural Information Processing Systems (2023).](https://md.research.elamur.ai/free/en/papers/paul-2023-refiner-reasoning-feedback-intermediate-representations/) [https://openreview.net/forum?id=Bw82hwg5Q3](https://openreview.net/forum?id=Bw82hwg5Q3). Paul, D., Ismayilzada, M., Peyrard, M., Borges, B., Bos… [↗](https://openreview.net/forum?id=Bw82hwg5Q3)
85. Zhao, A., Huang, D., Xu, Q., Lin, M., Liu, Y.-J. & Huang, G. Expel: Llm agents are experiential learners in Proceedings of the AAAI Conference on Artificial Intelligence 38 (2024), 19632–19642. [find](https://scholar.google.com/scholar?q=Zhao%2C+A%2E%2C+Huang%2C+D%2E%2C+Xu%2C+Q%2E%2C+Lin%2C+M%2E%2C+Liu%2C+Y%2E%2DJ%2E+%26+Huang%2C+G%2E+Expel%3A+Llm+agents+are+experiential+learners+in+Proceedings+of+the+AAAI+Conference+on+Artificial+Intelligence+38+%282024%29%2C+19632%E2%80%9319642%2E)
86. Le, H., Chen, H., Saha, A., Gokul, A., Sahoo, D. & Joty, S. CodeChain: Towards Modular Code Generation Through Chain of Self-revisions with Representative Sub-modules in The Twelfth International Conference on Learning Representations (2024). [https://openreview.net/forum?id=vYhglxSj8j](https://openreview.net/forum?id=vYhglxSj8j). [↗](https://openreview.net/forum?id=vYhglxSj8j)
87. Robbins, H. & Monro, S. A stochastic approximation method. The Annals of Mathematical Statistics, 400–407 (1951). [find](https://scholar.google.com/scholar?q=Robbins%2C+H%2E+%26+Monro%2C+S%2E+A+stochastic+approximation+method%2E+The+Annals+of+Mathematical+Statistics%2C+400%E2%80%93407+%281951%29%2E)
88. Lewis, P., Perez, E., Piktus, A., Petroni, F., Karpukhin, V., Goyal, N., Küttler, H., Lewis, M., Yih, W.-t., Rocktäschel, T., et al. Retrieval-augmented generation for knowledge-intensive nlp tasks. Advances in Neural Information Processing Systems 33, 9459–9474 (2020). [find](https://scholar.google.com/scholar?q=Lewis%2C+P%2E%2C+Perez%2C+E%2E%2C+Piktus%2C+A%2E%2C+Petroni%2C+F%2E%2C+Karpukhin%2C+V%2E%2C+Goyal%2C+N%2E%2C+K%C3%BCttler%2C+H%2E%2C+Lewis%2C+M%2E%2C+Yih%2C+W%2E%2Dt%2E%2C+Rockt%C3%A4schel%2C+T%2E%2C+et+al%2E+Retrieval%2Daugmented+generation+for+knowledge%2Dintensive+nlp+tasks%2E+A)
89. Robert, C. P. & Casella, G. Simulation and the Monte Carlo method. Springer Texts in Statistics, New York: Springer 2 (1999). [find](https://scholar.google.com/scholar?q=Robert%2C+C%2E+P%2E+%26+Casella%2C+G%2E+Simulation+and+the+Monte+Carlo+method%2E+Springer+Texts+in+Statistics%2C+New+York%3A+Springer+2+%281999%29%2E)
90. Kingma, D. & Ba, J. Adam: A Method for Stochastic Optimization in International Conference on Learning Representations (ICLR) (San Diega, CA, USA, 2015). [find](https://scholar.google.com/scholar?q=Kingma%2C+D%2E+%26+Ba%2C+J%2E+Adam%3A+A+Method+for+Stochastic+Optimization+in+International+Conference+on+Learning+Representations+%28ICLR%29+%28San+Diega%2C+CA%2C+USA%2C+2015%29%2E)
91. [Lightman, H., Kosaraju, V., Burda, Y., Edwards, H., Baker, B., Lee, T., Leike, J., Schulman, J., Sutskever, I. & Cobbe, K. Let’s Verify Step by Step in The Twelfth International Conference on Learning Representations (2024).](https://md.research.elamur.ai/free/en/papers/lightman-2023-let-s-verify-step-step/) [https://openreview.net/forum?id=v8L0pN6EOi](https://openreview.net/forum?id=v8L0pN6EOi). [↗](https://openreview.net/forum?id=v8L0pN6EOi)
92. Schmidhuber, J. Evolutionary Principles in Self-Referential Learning PhD thesis (Technical University of Munich, 1987). [find](https://scholar.google.com/scholar?q=Schmidhuber%2C+J%2E+Evolutionary+Principles+in+Self%2DReferential+Learning+PhD+thesis+%28Technical+University+of+Munich%2C+1987%29%2E)
93. Thrun, S. & Pratt, L. in Learning to Learn 3–17 (Springer, 1998). [find](https://scholar.google.com/scholar?q=Thrun%2C+S%2E+%26+Pratt%2C+L%2E+in+Learning+to+Learn+3%E2%80%9317+%28Springer%2C+1998%29%2E)
94. Finn, C., Abbeel, P. & Levine, S. Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks in Proceedings of the 34th International Conference on Machine Learning (2017). [find](https://scholar.google.com/scholar?q=Finn%2C+C%2E%2C+Abbeel%2C+P%2E+%26+Levine%2C+S%2E+Model%2DAgnostic+Meta%2DLearning+for+Fast+Adaptation+of+Deep+Networks+in+Proceedings+of+the+34th+International+Conference+on+Machine+Learning+%282017%29%2E)
95. RDKit: Open-source cheminformatics [http://www.rdkit.org](http://www.rdkit.org). [↗](http://www.rdkit.org)
96. Hughes, J. P., Rees, S., Kalindjian, S. B. & Philpott, K. L. Principles of early drug discovery. British journal of pharmacology 162, 1239–1249 (2011). [find](https://scholar.google.com/scholar?q=Hughes%2C+J%2E+P%2E%2C+Rees%2C+S%2E%2C+Kalindjian%2C+S%2E+B%2E+%26+Philpott%2C+K%2E+L%2E+Principles+of+early+drug+discovery%2E+British+journal+of+pharmacology+162%2C+1239%E2%80%931249+%282011%29%2E)
97. Wenlock, M. C., Austin, R. P., Barton, P., Davis, A. M. & Leeson, P. D. A comparison of physiochemical property profiles of development and marketed oral drugs. Journal of medicinal chemistry 46, 1250–1256 (2003). [find](https://scholar.google.com/scholar?q=Wenlock%2C+M%2E+C%2E%2C+Austin%2C+R%2E+P%2E%2C+Barton%2C+P%2E%2C+Davis%2C+A%2E+M%2E+%26+Leeson%2C+P%2E+D%2E+A+comparison+of+physiochemical+property+profiles+of+development+and+marketed+oral+drugs%2E+Journal+of+medicinal+chemistry+46%2C+1250)
98. Knox, C., Wilson, M., Klinger, C. M., Franklin, M., Oler, E., Wilson, A., Pon, A., Cox, J., Chin, N. E., Strawbridge, S. A., et al. Drugbank 6.0: the drugbank knowledgebase for 2024. Nucleic Acids Research 52, D1265–D1275 (2024). [find](https://scholar.google.com/scholar?q=Knox%2C+C%2E%2C+Wilson%2C+M%2E%2C+Klinger%2C+C%2E+M%2E%2C+Franklin%2C+M%2E%2C+Oler%2C+E%2E%2C+Wilson%2C+A%2E%2C+Pon%2C+A%2E%2C+Cox%2C+J%2E%2C+Chin%2C+N%2E+E%2E%2C+Strawbridge%2C+S%2E+A%2E%2C+et+al%2E+Drugbank+6%2E0%3A+the+drugbank+knowledgebase+for+2024%2E+Nucleic+Acids+Res)
99. Berry, M., Fielding, B. & Gamieldien, J. Practical considerations in virtual screening and molecular docking. Emerging trends in computational biology, bioinformatics, and systems biology, 487 (2015). [find](https://scholar.google.com/scholar?q=Berry%2C+M%2E%2C+Fielding%2C+B%2E+%26+Gamieldien%2C+J%2E+Practical+considerations+in+virtual+screening+and+molecular+docking%2E+Emerging+trends+in+computational+biology%2C+bioinformatics%2C+and+systems+biology%2C+487+%282015%29%2E)
100. Birhane, A., Kasirzadeh, A., Leslie, D. & Wachter, S. Science in the age of large language models. Nature Reviews Physics 5, 277–280 (2023). [find](https://scholar.google.com/scholar?q=Birhane%2C+A%2E%2C+Kasirzadeh%2C+A%2E%2C+Leslie%2C+D%2E+%26+Wachter%2C+S%2E+Science+in+the+age+of+large+language+models%2E+Nature+Reviews+Physics+5%2C+277%E2%80%93280+%282023%29%2E)
101. Nikolova, N. & Jaworska, J. Approaches to measure chemical similarity–a review. QSAR & Combinatorial Science 22, 1006–1026 (2003). [find](https://scholar.google.com/scholar?q=Nikolova%2C+N%2E+%26+Jaworska%2C+J%2E+Approaches+to+measure+chemical+similarity%E2%80%93a+review%2E+QSAR+%26+Combinatorial+Science+22%2C+1006%E2%80%931026+%282003%29%2E)
102. Gaulton, A., Bellis, L. J., Bento, A. P., Chambers, J., Davies, M., Hersey, A., Light, Y., McGlinchey, S., Michalovich, D., Al-Lazikani, B., et al. ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic acids research 40, D1100–D1107 (2012). [find](https://scholar.google.com/scholar?q=Gaulton%2C+A%2E%2C+Bellis%2C+L%2E+J%2E%2C+Bento%2C+A%2E+P%2E%2C+Chambers%2C+J%2E%2C+Davies%2C+M%2E%2C+Hersey%2C+A%2E%2C+Light%2C+Y%2E%2C+McGlinchey%2C+S%2E%2C+Michalovich%2C+D%2E%2C+Al%2DLazikani%2C+B%2E%2C+et+al%2E+ChEMBL%3A+a+large%2Dscale+bioactivity+database+for+drug+)
103. Swanson, K., Walther, P., Leitz, J., Mukherjee, S., Wu, J. C., Shivnaraine, R. V. & Zou, J. ADMET-AI: A machine learning ADMET platform for evaluation of large-scale chemical libraries. bioRxiv, 2023–12 (2023). [find](https://scholar.google.com/scholar?q=Swanson%2C+K%2E%2C+Walther%2C+P%2E%2C+Leitz%2C+J%2E%2C+Mukherjee%2C+S%2E%2C+Wu%2C+J%2E+C%2E%2C+Shivnaraine%2C+R%2E+V%2E+%26+Zou%2C+J%2E+ADMET%2DAI%3A+A+machine+learning+ADMET+platform+for+evaluation+of+large%2Dscale+chemical+libraries%2E+bioRxiv%2C+2023%E2%80%93)
104. Xing, L., Li, J. G., Donaldson, S., Le, Q. T. & Boyer, A. L. Optimization of Importance Factors in Inverse Planning. Physics in Medicine & Biology 44, 2525. ISSN : 0031-9155. (2024) (Oct. 1999). [find](https://scholar.google.com/scholar?q=Xing%2C+L%2E%2C+Li%2C+J%2E+G%2E%2C+Donaldson%2C+S%2E%2C+Le%2C+Q%2E+T%2E+%26+Boyer%2C+A%2E+L%2E+Optimization+of+Importance+Factors+in+Inverse+Planning%2E+Physics+in+Medicine+%26+Biology+44%2C+2525%2E+ISSN+%3A+0031%2D9155%2E+%282024%29+%28Oct%2E+1999%29%2E)

*Updated 24 October 2026*
