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title: "Nature 2021 — all accepted papers, page 2 — the most cited first"
description: "All 3,641 papers of Nature 2021 · page 2 of 37, the most cited first; those with our summary link to it."
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# Nature 2021: all accepted papers

3,641 papers · page 2 of 37 · the most cited first · [← Nature 2021](https://md.research.elamur.ai/free/en/venues/nature/2021/)

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101. **[Environmental performance of blue foods ↗](https://doi.org/10.1038/s41586-021-03889-2)**Jessica A. Gephart, Patrik J. G. Henriksson, Robert W. R. Parker et al.*677 citations*
102. **[Genome-wide enhancer maps link risk variants to disease genes ↗](https://doi.org/10.1038/s41586-021-03446-x)**Joseph Nasser, Drew T. Bergman, Charles P. Fulco et al.*661 citations*
103. **[Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma ↗](https://doi.org/10.1038/s41586-021-03471-w)**Network for Genomic Surveillance in, Sandile Cele, COMMIT-KZN Team et al.*649 citations*
104. **[Multi-omic machine learning predictor of breast cancer therapy response ↗](https://doi.org/10.1038/s41586-021-04278-5)**Stephen‐John Sammut, Mireia Crispin‐Ortuzar, Suet‐Feung Chin et al.*648 citations*
105. **[Aquatic foods to nourish nations ↗](https://doi.org/10.1038/s41586-021-03917-1)**Christopher De Weir Golden, J. Zachary Koehn, Alon Shepon et al.*646 citations*
106. **[ctDNA guiding adjuvant immunotherapy in urothelial carcinoma ↗](https://doi.org/10.1038/s41586-021-03642-9)**Thomas B. Powles, Zoe June F. Assaf, Nicole N. Davarpanah et al.*646 citations*
107. **[Copper-coordinated cellulose ion conductors for solid-state batteries ↗](https://doi.org/10.1038/s41586-021-03885-6)**Chunpeng Yang, Qisheng Wu, Weiqi Xie et al.*644 citations*
108. **[Gasdermin D pore structure reveals preferential release of mature interleukin-1 ↗](https://doi.org/10.1038/s41586-021-03478-3)**Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli et al.*642 citations*
109. **[Towards real-time photorealistic 3D holography with deep neural networks ↗](https://doi.org/10.1038/s41586-020-03152-0)**Liang Shi, Beichen Li, Changil Kim et al.*637 citations*
110. **[Survey of spiking in the mouse visual system reveals functional hierarchy ↗](https://doi.org/10.1038/s41586-020-03171-x)**Joshua H. Siegle, Xiaoxuan Jia, Séverine Durand et al.*634 citations*
111. **[Soil moisture–atmosphere feedback dominates land carbon uptake variability ↗](https://doi.org/10.1038/s41586-021-03325-5)**Vincent Humphrey, Alexis Berg, Philippe Ciais et al.*627 citations*
112. **[AI-based pathology predicts origins for cancers of unknown primary ↗](https://doi.org/10.1038/s41586-021-03512-4)**Ming Y. Lu, Tiffany Y. Chen, Drew F. K. Williamson et al.*623 citations*
113. **[Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians ↗](https://doi.org/10.1038/s41586-021-03832-5)**Yuko Sato, Koji Atarashi, Damian Rafal Plichta et al.*622 citations*
114. **[Orthogonal-array dynamic molecular sieving of propylene/propane mixtures ↗](https://doi.org/10.1038/s41586-021-03627-8)**Heng Zeng, Mo Xie, Ting Wang et al.*622 citations*
115. **[Roton pair density wave in a strong-coupling kagome superconductor ↗](https://doi.org/10.1038/s41586-021-03983-5)**Hui Chen, Haitao Yang, Bin Hu et al.*622 citations*
116. **[Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies ↗](https://doi.org/10.1038/s41586-021-03412-7)**Dami A. Collier, Anna De Marco, Isabella A.T.M. Ferreira et al.*622 citations*
117. **[Dysregulation of brain and choroid plexus cell types in severe COVID-19 ↗](https://doi.org/10.1038/s41586-021-03710-0)**Andrew C. Yang, Fabian Kern, Patricia Morán Losada et al.*617 citations*
118. **[Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation ↗](https://doi.org/10.1038/s41586-021-04266-9)**Akatsuki Saito, Takashi Irie, Rigel Suzuki et al.*615 citations*
119. **[De novo protein design by deep network hallucination ↗](https://doi.org/10.1038/s41586-021-04184-w)**Ivan V. Anishchenko, Samuel J. Pellock, Tamuka M. Chidyausiku et al.*614 citations*
120. **[A graph placement methodology for fast chip design ↗](https://doi.org/10.1038/s41586-021-03544-w)**Azalia Mirhoseini, Anna Goldie, Mustafa Yazgan et al.*612 citations*
121. **[Metabolic modulation of tumours with engineered bacteria for immunotherapy ↗](https://doi.org/10.1038/s41586-021-04003-2)**Fernando Pablo Canale, Camilla Basso, Gaia Antonini et al.*609 citations*
122. **[Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells ↗](https://doi.org/10.1038/s41586-021-03651-8)**María Casanova-Acebes, Erica Dalla, Andrew M. Leader et al.*600 citations*
123. **[Rare variant contribution to human disease in 281,104 UK Biobank exomes ↗](https://doi.org/10.1038/s41586-021-03855-y)**Quanli Wang, Ryan S. Dhindsa, Keren Carss et al.*595 citations*
124. **[Mastering the surface strain of platinum catalysts for efficient electrocatalysis ↗](https://doi.org/10.1038/s41586-021-03870-z)**Tianou He, Weicong Wang, Fenglei Shi et al.*583 citations*
125. **[Projected land ice contributions to twenty-first-century sea level rise ↗](https://doi.org/10.1038/s41586-021-03302-y)**Tamsin Edwards, Sophie Nowicki, Ben Marzeion et al.*583 citations*
126. **[Global prevalence of non-perennial rivers and streams ↗](https://doi.org/10.1038/s41586-021-03565-5)**Mathis Messager, Bernhard Lehner, Charlotte Cockburn et al.*581 citations*
127. **[A stable low-temperature H2-production catalyst by crowding Pt on α-MoC ↗](https://doi.org/10.1038/s41586-020-03130-6)**Xiao Zhang, Mengtao Zhang, Yuchen Deng et al.*574 citations*
128. **[Global and regional drivers of land-use emissions in 1961–2017 ↗](https://doi.org/10.1038/s41586-020-03138-y)**Chaopeng Hong, Jennifer Anne Burney, Julia Pongratz et al.*574 citations*
129. **[The N501Y spike substitution enhances SARS-CoV-2 infection and transmission ↗](https://doi.org/10.1038/s41586-021-04245-0)**Yang Liu, Jianying Liu, Kenneth S. Plante et al.*572 citations*
130. **[Neurotoxic reactive astrocytes induce cell death via saturated lipids ↗](https://doi.org/10.1038/s41586-021-03960-y)**Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash et al.*571 citations*
131. **[Non-reciprocal phase transitions ↗](https://doi.org/10.1038/s41586-021-03375-9)**Michel Fruchart, Ryo Hanai, Peter B. Littlewood et al.*567 citations*
132. **[Quantum circuits with many photons on a programmable nanophotonic chip ↗](https://doi.org/10.1038/s41586-021-03202-1)**J. M. Arrazola, V. Bergholm, K. Brádler et al.*564 citations*
133. **[A highly stable and flexible zeolite electrolyte solid-state Li–air battery ↗](https://doi.org/10.1038/s41586-021-03410-9)**Xiwen Chi, Malin Li, Jiancheng Di et al.*562 citations*
134. **[Globally resolved surface temperatures since the Last Glacial Maximum ↗](https://doi.org/10.1038/s41586-021-03984-4)**Matthew Osman, Jessica E. Tierney, Jiang Zhu et al.*562 citations*
135. **[Quantum anomalous Hall effect from intertwined moiré bands ↗](https://doi.org/10.1038/s41586-021-04171-1)**Tingxin Li, Shengwei Jiang, Bowen Shen et al.*562 citations*
136. **[Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma ↗](https://doi.org/10.1038/s41586-021-03704-y)**Giacomo Oliveira, Kari Stromhaug, Susan Klaeger et al.*558 citations*
137. **[Systems vaccinology of the BNT162b2 mRNA vaccine in humans ↗](https://doi.org/10.1038/s41586-021-03791-x)**Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan et al.*558 citations*
138. **[Scalable production of high-performing woven lithium-ion fibre batteries ↗](https://doi.org/10.1038/s41586-021-03772-0)**Jiqing He, Chenhao Lu, Haibo Jiang et al.*557 citations*
139. **[Molecular architecture of the developing mouse brain ↗](https://doi.org/10.1038/s41586-021-03775-x)**Gioele La Manno, Kimberly Siletti, Alessandro Furlan et al.*555 citations*
140. **[Net-zero emissions targets are vague: three ways to fix ↗](https://doi.org/10.1038/d41586-021-00662-3)**Joeri Rogelj, Oliver Geden, Annette Cowie et al.*554 citations*
141. **[Heavily mutated Omicron variant puts scientists on alert ↗](https://doi.org/10.1038/d41586-021-03552-w)**Ewen Callaway*553 citations*
142. **[A reprogrammable mechanical metamaterial with stable memory ↗](https://doi.org/10.1038/s41586-020-03123-5)**Tian Chen, Mark Pauly, Pedro M. Reis*550 citations*
143. **[Demonstration of the trapped-ion quantum CCD computer architecture ↗](https://doi.org/10.1038/s41586-021-03318-4)**J. M. Pino, J. M. Dreiling, C. Figgatt et al.*546 citations*
144. **[Disruption of mitochondrial complex I induces progressive parkinsonism ↗](https://doi.org/10.1038/s41586-021-04059-0)**Patricia González‐Rodríguez, Enrico Zampese, Kristen A. Stout et al.*546 citations*
145. **[The Paris Climate Agreement and future sea-level rise from Antarctica ↗](https://doi.org/10.1038/s41586-021-03427-0)**Robert M. DeConto, David Pollard, Richard B. Alley et al.*546 citations*
146. **[Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers ↗](https://doi.org/10.1038/s41586-021-03752-4)**Justina X. Caushi, Jiajia Zhang, Zhicheng Ji et al.*543 citations*
147. **[The tangled history of mRNA vaccines ↗](https://doi.org/10.1038/d41586-021-02483-w)**Elie Dolgin*542 citations*
148. **[Overriding water table control on managed peatland greenhouse gas emissions ↗](https://doi.org/10.1038/s41586-021-03523-1)**Chris Evans, Mike Peacock, Andy J. Baird et al.*539 citations*
149. **[SARS-CoV-2 spike D614G change enhances replication and transmission ↗](https://doi.org/10.1038/s41586-021-03361-1)**Bin Zhou, Tran Thi Nhu Thao, Donata Hoffmann et al.*537 citations*
150. **[SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans ↗](https://doi.org/10.1038/s41586-021-03647-4)**Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina et al.*529 citations*
151. **[Somatic mutation landscapes at single-molecule resolution ↗](https://doi.org/10.1038/s41586-021-03477-4)**Federico Abascal, Luke M. R. Harvey, Emily Mitchell et al.*526 citations*
152. **[Ultrahigh-energy photons up to 1.4 petaelectronvolts from 12 γ-ray Galactic sources ↗](https://doi.org/10.1038/s41586-021-03498-z)**Z. Cao, Z. Cao, F. Aharonian et al.*525 citations*
153. **[Fractional Chern insulators in magic-angle twisted bilayer graphene ↗](https://doi.org/10.1038/s41586-021-04002-3)**Yonglong Xie, Andrew T. Pierce, Jeong Min Park et al.*523 citations*
154. **[The rise of intelligent matter ↗](https://doi.org/10.1038/s41586-021-03453-y)**Corinna Kaspar, Bart Jan Ravoo, Wilfred G. van der Wiel et al.*522 citations*
155. **[A multimodal cell census and atlas of the mammalian primary motor cortex ↗](https://doi.org/10.1038/s41586-021-03950-0)**BRAIN Initiative Cell Census Network (BICCN), BRAIN Initiative Cell Census Network (BICCN) Corresponding authors, Edward M. Callaway et al.*518 citations*
156. **[Restoring metabolism of myeloid cells reverses cognitive decline in ageing ↗](https://doi.org/10.1038/s41586-020-03160-0)**Paras Singh Minhas, Amira Latif‐Hernandez, Melanie R. McReynolds et al.*515 citations*
157. **[SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape ↗](https://doi.org/10.1038/s41586-021-03807-6)**Tyler N. Starr, Nadine Czudnochowski, Zhuoming Liu et al.*515 citations*
158. **[Cascade of correlated electron states in the kagome superconductor CsV3Sb5 ↗](https://doi.org/10.1038/s41586-021-03946-w)**He Zhao, Hong Li, Brenden R. Ortiz et al.*513 citations*
159. **[Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH ↗](https://doi.org/10.1038/s41586-021-03233-8)**Michael Dudek, Dominik Reinhard Pfister, Sainitin Donakonda et al.*505 citations*
160. **[Cycling cancer persister cells arise from lineages with distinct programs ↗](https://doi.org/10.1038/s41586-021-03796-6)**Yaara Oren, Michael Tsabar, Michael S. Cuoco et al.*502 citations*
161. **[Blastocyst-like structures generated from human pluripotent stem cells ↗](https://doi.org/10.1038/s41586-021-03356-y)**Leqian Yu, Yulei Wei, Jialei Duan et al.*501 citations*
162. **[Human alteration of global surface water storage variability ↗](https://doi.org/10.1038/s41586-021-03262-3)**S. Cooley, Jonathan C. Ryan, L. C. Smith*500 citations*
163. **[Human blastoids model blastocyst development and implantation ↗](https://doi.org/10.1038/s41586-021-04267-8)**Harunobu Kagawa, Alok Javali, Heidar Heidari Khoei et al.*498 citations*
164. **[Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH ↗](https://doi.org/10.1038/s41586-021-03705-x)**Meng Zhang, Stephen W. Eichhorn, Brian Zingg et al.*491 citations*
165. **[Independent infections of porcine deltacoronavirus among Haitian children ↗](https://doi.org/10.1038/s41586-021-04111-z)**John A. Lednicky, Massimiliano S. Tagliamonte, Sarah K. White et al.*487 citations*
166. **[In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice ↗](https://doi.org/10.1038/s41586-020-03086-7)**Luke W. Koblan, Michael R. Erdos, Christopher Wilson et al.*483 citations*
167. **[A global inventory of photovoltaic solar energy generating units ↗](https://doi.org/10.1038/s41586-021-03957-7)**Lucas Kruitwagen, Kyle T. Story, Jürgen Friedrich et al.*481 citations*
168. **[Single-cell transcriptomic characterization of a gastrulating human embryo ↗](https://doi.org/10.1038/s41586-021-04158-y)**Richard C. V. Tyser, Elmir Mahammadov, Shota Nakanoh et al.*479 citations*
169. **[Structure-based classification predicts drug response in EGFR-mutant NSCLC ↗](https://doi.org/10.1038/s41586-021-03898-1)**Jacqulyne Ponville Robichaux, Xiuning Le, R. S. K. Vijayan et al.*479 citations*
170. **[Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron ↗](https://doi.org/10.1038/s41586-022-04399-5)**Juan Manuel Carreño, Hala Alshammary, Johnstone Tcheou et al.*478 citations*
171. **[Improving reporting standards for polygenic scores in risk prediction studies ↗](https://doi.org/10.1038/s41586-021-03243-6)**Hannah Wand, Samuel A. Lambert, Cecelia P. Tamburro et al.*471 citations*
172. **[Diverse alterations associated with resistance to KRAS(G12C) inhibition ↗](https://doi.org/10.1038/s41586-021-04065-2)**Yulei Zhao, Yonina R. Murciano‐Goroff, Jenny Y. Xue et al.*469 citations*
173. **[Lake heatwaves under climate change ↗](https://doi.org/10.1038/s41586-020-03119-1)**Richard Iestyn Woolway, Eleanor Jennings, Tom Shatwell et al.*466 citations*
174. **[Genomic basis of geographical adaptation to soil nitrogen in rice ↗](https://doi.org/10.1038/s41586-020-03091-w)**Yongqiang Liu, Hongru Wang, Zhimin Jiang et al.*465 citations*
175. **[Behavioural nudges increase COVID-19 vaccinations ↗](https://doi.org/10.1038/s41586-021-03843-2)**Hengchen Dai, Silvia Saccardo, Maria A. Han et al.*462 citations*
176. **[The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis ↗](https://doi.org/10.1038/s41586-021-03341-5)**Trevor P. Fidler, Chenyi Xue, Mustafa Yalçınkaya et al.*462 citations*
177. **[Molecular logic of cellular diversification in the mouse cerebral cortex ↗](https://doi.org/10.1038/s41586-021-03670-5)**Daniela J. Di Bella, Ehsan Habibi, Robert R. Stickels et al.*459 citations*
178. **[Core-collapse supernova explosion theory ↗](https://doi.org/10.1038/s41586-020-03059-w)**Adam S. Burrows, D. Vartanyan*458 citations*
179. **[Interpreting type 1 diabetes risk with genetics and single-cell epigenomics ↗](https://doi.org/10.1038/s41586-021-03552-w)**Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino et al.*458 citations*
180. **[Phase separation drives aberrant chromatin looping and cancer development ↗](https://doi.org/10.1038/s41586-021-03662-5)**Jeong Hyun Ahn, Eric S. Davis, Timothy A. Daugird et al.*457 citations*
181. **[B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity ↗](https://doi.org/10.1038/s41586-021-04082-1)**Baihao Zhang, Alexis Vogelzang, Michio Miyajima et al.*455 citations*
182. **[The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity ↗](https://doi.org/10.1038/s41586-021-03829-0)**Rory N. Pruitt, Federica Locci, Friederike Wanke et al.*455 citations*
183. **[Identification of bacteria-derived HLA-bound peptides in melanoma ↗](https://doi.org/10.1038/s41586-021-03368-8)**Shelly Kalaora, Adi Nagler, Deborah Nejman et al.*453 citations*
184. **[Two-billion-year-old volcanism on the Moon from Chang’e-5 basalts ↗](https://doi.org/10.1038/s41586-021-04100-2)**Qiuli Li, Qin Zhou, Yu Liu et al.*452 citations*
185. **[Advancing mathematics by guiding human intuition with AI ↗](https://doi.org/10.1038/s41586-021-04086-x)**Alex Davies, Petar Veličković, Lars Buesing et al.*451 citations*
186. **[A proximity-dependent biotinylation map of a human cell ↗](https://doi.org/10.1038/s41586-021-03592-2)**Christopher D. Go, James D.R. Knight, Archita Rajasekharan et al.*450 citations*
187. **[Biologically informed deep neural network for prostate cancer discovery ↗](https://doi.org/10.1038/s41586-021-03922-4)**Haitham Elmarakeby, Justin H. Hwang, Rand Arafeh et al.*450 citations*
188. **[The role of charge recombination to triplet excitons in organic solar cells ↗](https://doi.org/10.1038/s41586-021-03840-5)**Alexander J. Gillett, Alberto Privitera, Rishat Dilmurat et al.*450 citations*
189. **[A clinically applicable integrative molecular classification of meningiomas ↗](https://doi.org/10.1038/s41586-021-03850-3)**Farshad Nassiri, Jeff Liu, Vikas S. Patil et al.*449 citations*
190. **[Function and regulation of the divisome for mitochondrial fission ↗](https://doi.org/10.1038/s41586-021-03214-x)**Felix Kraus, Krishnendu Roy, Thomas John Pucadyil et al.*446 citations*
191. **[Genomic insights into the formation of human populations in East Asia ↗](https://doi.org/10.1038/s41586-021-03336-2)**Chuan‐Chao Wang, Hui‐Yuan Yeh, А. N. Popov et al.*442 citations*
192. **[EGFR activation limits the response of liver cancer to lenvatinib ↗](https://doi.org/10.1038/s41586-021-03741-7)**Haojie Jin, Yaoping Shi, Yuanyuan Lv et al.*440 citations*
193. **[Superconductivity in rhombohedral trilayer graphene ↗](https://doi.org/10.1038/s41586-021-03926-0)**Haoxin Zhou, Tian Xie, Takashi Taniguchi et al.*438 citations*
194. **[The coronavirus is here to stay — here’s what that means ↗](https://doi.org/10.1038/d41586-021-00396-2)**Nicky Phillips*437 citations*
195. **[Multistable inflatable origami structures at the metre scale ↗](https://doi.org/10.1038/s41586-021-03407-4)**David Melancon, Benjamin Gorissen, Carlos J. García-Mora et al.*433 citations*
196. **[A vaccine targeting mutant IDH1 in newly diagnosed glioma ↗](https://doi.org/10.1038/s41586-021-03363-z)**Michael Platten, Lukas Bunse, Antje Wick et al.*432 citations*
197. **[Metallaphotoredox-enabled deoxygenative arylation of alcohols ↗](https://doi.org/10.1038/s41586-021-03920-6)**Zhe Dong, David W. C. MacMillan*432 citations*
198. **[Magnetic sensitivity of cryptochrome 4 from a migratory songbird ↗](https://doi.org/10.1038/s41586-021-03618-9)**Jingjing Xu, Lauren E. Jarocha, Tilo M. Zollitsch et al.*431 citations*
199. **[Genetic insights into biological mechanisms governing human ovarian ageing ↗](https://doi.org/10.1038/s41586-021-03779-7)**Katherine S. Ruth, Felix R. Day, Jazib Hussain et al.*428 citations*
200. **[After the pandemic: perspectives on the future trajectory of COVID-19 ↗](https://doi.org/10.1038/s41586-021-03792-w)**Amalio Telenti, Ann M. Arvin, Lawrence Corey et al.*426 citations*

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