---
title: "Nature 2021 — all accepted papers, page 7 — the most cited first"
description: "All 3,641 papers of Nature 2021 · page 7 of 37, the most cited first; those with our summary link to it."
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# Nature 2021: all accepted papers

3,641 papers · page 7 of 37 · the most cited first · [← Nature 2021](https://md.research.elamur.ai/free/en/venues/nature/2021/)

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601. **[Oxygen isotopes trace the origins of Earth’s earliest continental crust ↗](https://doi.org/10.1038/s41586-021-03337-1)**Robert H. Smithies, Yongjun Lu, Christopher L. Kirkland et al.*158 citations*
602. **[Reset of hippocampal–prefrontal circuitry facilitates learning ↗](https://doi.org/10.1038/s41586-021-03272-1)**Alan Jung Park, Alexander Z. Harris, Kelly Marie Martyniuk et al.*158 citations*
603. **[Strongly reducing magnesium(0) complexes ↗](https://doi.org/10.1038/s41586-021-03401-w)**Bastian Rösch, Thomas Xaver Gentner, Jonathan Eyselein et al.*158 citations*
604. **[Systematic analysis of binding of transcription factors to noncoding variants ↗](https://doi.org/10.1038/s41586-021-03211-0)**Jian Yan, Yunjiang Qiu, André Maurício Ribeiro dos Santos et al.*158 citations*
605. **[High aboveground carbon stock of African tropical montane forests ↗](https://doi.org/https://doi.org/10.1038/s41586-021-03728-4)**Aida Cuní‐Sanchez, Martin J. P. Sullivan, Philip J. Platts et al.*157 citations*
606. **[Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia ↗](https://doi.org/10.1038/s41586-021-03897-2)**Christopher J. Draper-Joyce, Rebecca F. Bhola, Jinan Wang et al.*157 citations*
607. **[Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit ↗](https://doi.org/10.1038/s41586-021-03830-7)**Filipa Cardoso, Roel G. J. Klein Wolterink, Cristina Godinho‐Silva et al.*156 citations*
608. **[Protecting a bosonic qubit with autonomous quantum error correction ↗](https://doi.org/10.1038/s41586-021-03257-0)**Jeffrey M. Gertler, Brian Baker, Juliang Li et al.*156 citations*
609. **[Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4 ↗](https://doi.org/10.1038/s41586-021-03495-2)**Shuling Lin, Shuo Han, Xiaoqing Cai et al.*156 citations*
610. **[The broken $100-billion promise of climate finance — and how to fix it ↗](https://doi.org/10.1038/d41586-021-02846-3)**Jocelyn Timperley*156 citations*
611. **[Viscoelastic control of spatiotemporal order in bacterial active matter ↗](https://doi.org/10.1038/s41586-020-03168-6)**Song Liu, Suraj Shankar, M. Cristina Marchetti et al.*156 citations*
612. **[ER proteins decipher the tubulin code to regulate organelle distribution ↗](https://doi.org/10.1038/s41586-021-04204-9)**Pengli Zheng, Christopher John Obara, Ewa Szczęsna et al.*155 citations*
613. **[Pleistocene sediment DNA reveals hominin and faunal turnovers at Denisova Cave ↗](https://doi.org/10.1038/s41586-021-03675-0)**Elena Irene Zavala, Zenobia L. Jacobs, Benjamin Vernot et al.*155 citations*
614. **[Time-resolved structural analysis of an RNA-cleaving DNA catalyst ↗](https://doi.org/10.1038/s41586-021-04225-4)**Jan Borggräfe, Julian Victor, Hannah Rosenbach et al.*155 citations*
615. **[Widespread potential loss of streamflow into underlying aquifers across the USA ↗](https://doi.org/10.1038/s41586-021-03311-x)**Scott Jasechko, Hansjörg Seybold, Debra Perrone et al.*155 citations*
616. **[Genetic dissection of the glutamatergic neuron system in cerebral cortex ↗](https://doi.org/10.1038/s41586-021-03955-9)**Katherine S. Matho, Dhananjay Huilgol, William Galbavy et al.*154 citations*
617. **[Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants ↗](https://doi.org/10.1038/s41586-021-04117-7)**Emanuele Andreano, Ida Paciello, Giulia Piccini et al.*154 citations*
618. **[Structural basis of long-range to short-range synaptic transition in NHEJ ↗](https://doi.org/10.1038/s41586-021-03458-7)**Siyu Chen, Linda Lee, Tasmin Naila et al.*154 citations*
619. **[Coronavirus variants are spreading in India — what scientists know so far ↗](https://doi.org/10.1038/d41586-021-01274-7)**Gayathri Vaidyanathan*153 citations*
620. **[Non-genetic determinants of malignant clonal fitness at single-cell resolution ↗](https://doi.org/10.1038/s41586-021-04206-7)**Katie A. Fennell, Dane Vassiliadis, Enid Y.N. Lam et al.*153 citations*
621. **[Clonal fitness inferred from time-series modelling of single-cell cancer genomes ↗](https://doi.org/10.1038/s41586-021-03648-3)**Sohrab Salehi, Farhia Kabeer, Nicholas Ceglia et al.*152 citations*
622. **[Dairying enabled Early Bronze Age Yamnaya steppe expansions ↗](https://doi.org/10.1038/s41586-021-03798-4)**Shevan Wilkin, Alicia Ventresca Miller, Ricardo Fernandes et al.*152 citations*
623. **[Warming impairs trophic transfer efficiency in a long-term field experiment ↗](https://doi.org/10.1038/s41586-021-03352-2)**Diego R. Barneche, Chris J. Hulatt, Matteo Dossena et al.*152 citations*
624. **[Poleward and weakened westerlies during Pliocene warmth ↗](https://doi.org/10.1038/s41586-020-03062-1)**Jordan T. Abell, Gisela Winckler, Robert Frederick Anderson et al.*151 citations*
625. **[Possible poriferan body fossils in early Neoproterozoic microbial reefs ↗](https://doi.org/10.1038/s41586-021-03773-z)**Elizabeth C. Turner*151 citations*
626. **[Two cGAS-like receptors induce antiviral immunity in Drosophila ↗](https://doi.org/10.1038/s41586-021-03800-z)**Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad et al.*151 citations*
627. **[Integrated photonics enables continuous-beam electron phase modulation ↗](https://doi.org/10.1038/s41586-021-04197-5)**Jan-Wilke Henke, Arslan Sajid Raja, Armin Feist et al.*150 citations*
628. **[Liquid-induced topological transformations of cellular microstructures ↗](https://doi.org/10.1038/s41586-021-03404-7)**Shucong Li, Bolei Deng, Alison Grinthal et al.*150 citations*
629. **[Observation of Stark many-body localization without disorder ↗](https://doi.org/10.1038/s41586-021-03988-0)**William Morong, Fangli Liu, Patrick Becker et al.*150 citations*
630. **[Single-photon nonlinearity at room temperature ↗](https://doi.org/10.1038/s41586-021-03866-9)**Anton V. Zasedatelev, Anton V. Baranikov, Denis Sannikov et al.*150 citations*
631. **[Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1 ↗](https://doi.org/10.1038/s41586-021-03721-x)**Qiuyan Chen, Manolo D. Plasencia, Zhuang Li et al.*150 citations*
632. **[Transforming representations of movement from body- to world-centric space ↗](https://doi.org/10.1038/s41586-021-04191-x)**Jenny Lu, Amir H. Behbahani, Lydia Hamburg et al.*150 citations*
633. **[Elevated NSD3 histone methylation activity drives squamous cell lung cancer ↗](https://doi.org/10.1038/s41586-020-03170-y)**Gang Yuan, Natasha Mahealani Flores, Simone Hausmann et al.*149 citations*
634. **[Extreme flow simulations reveal skeletal adaptations of deep-sea sponges ↗](https://doi.org/10.1038/s41586-021-03658-1)**Giacomo Falcucci, Giorgio Amati, Pierluigi Fanelli et al.*149 citations*
635. **[G-protein activation by a metabotropic glutamate receptor ↗](https://doi.org/10.1038/s41586-021-03680-3)**Alpay Burak Seven, Ximena Barros-Álvarez, Marine de Lapeyrière et al.*149 citations*
636. **[Neural control of affiliative touch in prosocial interaction ↗](https://doi.org/10.1038/s41586-021-03962-w)**Ye Emily Wu, James Dang, Lyle Kingsbury et al.*149 citations*
637. **[A single-molecule van der Waals compass ↗](https://doi.org/10.1038/s41586-021-03429-y)**Boyuan Shen, Xiao Chen, Huiqiu Wang et al.*148 citations*
638. **[Ethics of DNA research on human remains: five globally applicable guidelines ↗](https://doi.org/10.1038/s41586-021-04008-x)**Songül Alpaslan-Roodenberg, David W. Anthony, Hiba Mohammed Ali Babiker et al.*148 citations*
639. **[Measuring phonon dispersion at an interface ↗](https://doi.org/10.1038/s41586-021-03971-9)**Ruishi Qi, Ruochen Shi, Yuehui Li et al.*148 citations*
640. **[Structural basis of human transcription–DNA repair coupling ↗](https://doi.org/10.1038/s41586-021-03906-4)**Goran Kokić, Felix Wagner, Aleksandar Chernev et al.*148 citations*
641. **[Enhancer release and retargeting activates disease-susceptibility genes ↗](https://doi.org/10.1038/s41586-021-03577-1)**Soohwan Oh, Jiaofang Shao, Joydeep Mitra et al.*147 citations*
642. **[Extensive phylogenies of human development inferred from somatic mutations ↗](https://doi.org/10.1038/s41586-021-03790-y)**Tim H. H. Coorens, Luiza Moore, Philip S. Robinson et al.*147 citations*
643. **[Decision makers need constantly updated evidence synthesis ↗](https://doi.org/10.1038/d41586-021-03690-1)**Julian Elliott, Rebecca N Lawrence, Jan Christoph Minx et al.*146 citations*
644. **[How far will global population rise? Researchers can’t agree ↗](https://doi.org/10.1038/d41586-021-02522-6)**David Adam*146 citations*
645. **[Structure and mechanism of the SGLT family of glucose transporters ↗](https://doi.org/10.1038/s41586-021-04211-w)**Lei Han, Qianhui Qu, Deniz Aydın et al.*146 citations*
646. **[Demonstration of a trapped-ion atomic clock in space ↗](https://doi.org/10.1038/s41586-021-03571-7)**Eric A. Burt, John D. Prestage, Robert L. Tjoelker et al.*145 citations*
647. **[Spatial maps in piriform cortex during olfactory navigation ↗](https://doi.org/10.1038/s41586-021-04242-3)**Cindy Poo, Gautam Agarwal, Niccolò Bonacchi et al.*145 citations*
648. **[Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter ↗](https://doi.org/10.1038/s41586-021-04212-9)**Yange Niu, Rui Liu, Chengcheng Guan et al.*145 citations*
649. **[Dopamine facilitates associative memory encoding in the entorhinal cortex ↗](https://doi.org/10.1038/s41586-021-03948-8)**Jason Y. Lee, Heechul Jun, Shogo Soma et al.*144 citations*
650. **[Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection ↗](https://doi.org/10.1038/s41586-021-04280-x)**Sarah Adamo, Jan Michler, Yves Zurbuchen et al.*144 citations*
651. **[Day–night cloud asymmetry prevents early oceans on Venus but not on Earth ↗](https://doi.org/10.1038/s41586-021-03873-w)**Martin Turbet, Émeline Bolmont, Guillaume Chaverot et al.*143 citations*
652. **[Diversity-oriented synthesis of polymer membranes with ion solvation cages ↗](https://doi.org/10.1038/s41586-021-03377-7)**Miranda J. Baran, Mark E. Carrington, Swagat Sahu et al.*143 citations*
653. **[The TOR–EIN2 axis mediates nuclear signalling to modulate plant growth ↗](https://doi.org/10.1038/s41586-021-03310-y)**Liwen Fu, Yanlin Liu, Guochen Qin et al.*143 citations*
654. **[Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans ↗](https://doi.org/10.1038/s41586-021-03671-4)**Omar Delannoy-Bruno, Chandni Desai, Arjun S. Raman et al.*142 citations*
655. **[Measuring algorithmically infused societies ↗](https://doi.org/10.1038/s41586-021-03666-1)**Claudia Wagner, Markus Strohmaier, Alexandra Olteanu et al.*142 citations*
656. **[Parallelism of intestinal secretory IgA shapes functional microbial fitness ↗](https://doi.org/10.1038/s41586-021-03973-7)**Tim Rollenske, Sophie Burkhalter, Lukas Muerner et al.*142 citations*
657. **[Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 ↗](https://doi.org/10.1038/s41586-021-03320-w)**Menghang Huang, Xiaoxiao Zhang, Gee Ann Toh et al.*142 citations*
658. **[Clonal dynamics in early human embryogenesis inferred from somatic mutation ↗](https://doi.org/10.1038/s41586-021-03786-8)**Seongyeol Park, Nanda Maya Mali, Ryul Kim et al.*141 citations*
659. **[Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine ↗](https://doi.org/10.1038/s41586-021-03692-z)**Guotong Fu, Clifford S. Guy, Nicole M. Chapman et al.*141 citations*
660. **[Tiny robots and sensors need tiny batteries — here’s how to do it ↗](https://doi.org/10.1038/d41586-021-00021-2)**Minshen Zhu, Oliver G. Schmidt*141 citations*
661. **[HP1 drives de novo 3D genome reorganization in early Drosophila embryos ↗](https://doi.org/10.1038/s41586-021-03460-z)**Fides Lea Zenk, Yinxiu Zhan, Pavel I. Kos et al.*140 citations*
662. **[Landmark Alzheimer’s drug approval confounds research community ↗](https://doi.org/10.1038/d41586-021-01546-2)**Asher Mullard*140 citations*
663. **[Metastability of diamond ramp-compressed to 2 terapascals ↗](https://doi.org/10.1038/s41586-020-03140-4)**Amy E. Lazicki, D. McGonegle, James R. Rygg et al.*140 citations*
664. **[Rational design of a new antibiotic class for drug-resistant infections ↗](https://doi.org/10.1038/s41586-021-03899-0)**Thomas F. Durand-Réville, Alita A. Miller, John P. O’Donnell et al.*140 citations*
665. **[MC3R links nutritional state to childhood growth and the timing of puberty ↗](https://doi.org/10.1038/s41586-021-04088-9)**Brian Lam, Alice Williamson, Sarah Finer et al.*139 citations*
666. **[Reverse-translational identification of a cerebellar satiation network ↗](https://doi.org/10.1038/s41586-021-04143-5)**Aloysius Y. T. Low, Nitsan Goldstein, Jessica Ruth Gaunt et al.*139 citations*
667. **[Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response ↗](https://doi.org/10.1038/s41586-021-04133-7)**Lee Mulderrig, Juan I. Garaycoechea, Zewen Kelvin Tuong et al.*138 citations*
668. **[Normal, dust-obscured galaxies in the epoch of reionization ↗](https://doi.org/10.1038/s41586-021-03846-z)**Y. Fudamoto, Pascal A. Oesch, S. Schouws et al.*138 citations*
669. **[Obesity accelerates hair thinning by stem cell-centric converging mechanisms ↗](https://doi.org/10.1038/s41586-021-03624-x)**Hironobu Morinaga, Yasuaki Mohri, Marina A. Grachtchouk et al.*138 citations*
670. **[Sexual arousal gates visual processing during Drosophila courtship ↗](https://doi.org/10.1038/s41586-021-03714-w)**Tom Hindmarsh Sten, Rufei Li, Adriane G. Otopalik et al.*138 citations*
671. **[A decline in emissions of CFC-11 and related chemicals from eastern China ↗](https://doi.org/10.1038/s41586-021-03277-w)**Sunyoung Park, Luke M. Western, Takuya Saito et al.*137 citations*
672. **[A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease ↗](https://doi.org/10.1038/s41586-021-03484-5)**Shikha Nayar, Joshua K. Morrison, Mamta Giri et al.*137 citations*
673. **[Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice ↗](https://doi.org/10.1038/s41586-021-03461-y)**Raoul De Gasparo, Mattia Pedotti, Luca Simonelli et al.*137 citations*
674. **[Decision trees within a molecular memristor ↗](https://doi.org/10.1038/s41586-021-03748-0)**Sreetosh Goswami, Rajib Pramanick, Abhijeet Patra et al.*137 citations*
675. **[Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface ↗](https://doi.org/10.1038/s41586-021-04084-z)**Devan C. Diwanji, Raphael Trenker, Tarjani M. Thaker et al.*137 citations*
676. **[Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation ↗](https://doi.org/10.1038/s41586-021-03716-8)**Qi Hu, Maria Victoria Botuyan, Debiao Zhao et al.*136 citations*
677. **[Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine ↗](https://doi.org/10.1038/s41586-021-03533-z)**Yizhi Sun, Janane F. Rahbani, Mark P. Jedrychowski et al.*136 citations*
678. **[Precise date for the Laacher See eruption synchronizes the Younger Dryas ↗](https://doi.org/10.1038/s41586-021-03608-x)**Frederick Reinig, Lukas Wacker, Olaf Jöris et al.*136 citations*
679. **[Regulated control of gene therapies by drug-induced splicing ↗](https://doi.org/10.1038/s41586-021-03770-2)**Alex Mas, Amiel A. Hundley, Paul T. Ranum et al.*136 citations*
680. **[Visualization of the mechanosensitive ion channel MscS under membrane tension ↗](https://doi.org/10.1038/s41586-021-03196-w)**Yixiao Zhang, Csaba Daday, Ruo‐Xu Gu et al.*136 citations*
681. **[ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma ↗](https://doi.org/10.1038/s41586-021-03515-1)**Ivana Yen, Frances Shanahan, Jeeyun Lee et al.*135 citations*
682. **[Measuring the α-particle charge radius with muonic helium-4 ions ↗](https://doi.org/10.1038/s41586-021-03183-1)**Julian J. Krauth, Karsten Schuhmann, Marwan Abdou Ahmed et al.*135 citations*
683. **[Structure of the human Mediator–RNA polymerase II pre-initiation complex ↗](https://doi.org/10.1038/s41586-021-03555-7)**Srinivasan Rengachari, S. Schilbach, Shintaro Aibara et al.*135 citations*
684. **[Asymmetric activation of the calcium-sensing receptor homodimer ↗](https://doi.org/10.1038/s41586-021-03691-0)**Yang Gao, Michael J. Robertson, Sabrina N. Rahman et al.*134 citations*
685. **[Entangling logical qubits with lattice surgery ↗](https://doi.org/10.1038/s41586-020-03079-6)**Alexander Erhard, Hendrik Poulsen Nautrup, Michael Meth et al.*134 citations*
686. **[Expansible residence decentralizes immune homeostasis ↗](https://doi.org/10.1038/s41586-021-03351-3)**Sathi Wijeyesinghe, Lalit K. Beura, Mark J. Pierson et al.*134 citations*
687. **[Rewiring of the ubiquitinated proteome determines ageing in C. elegans ↗](https://doi.org/10.1038/s41586-021-03781-z)**Seda Koyuncu, Rute Loureiro, Hyun Ju Lee et al.*134 citations*
688. **[Structural basis of omega-3 fatty acid transport across the blood–brain barrier ↗](https://doi.org/10.1038/s41586-021-03650-9)**Rosemary Jane Cater, Geok Lin Chua, Satchal K. Erramilli et al.*134 citations*
689. **[Mouse prefrontal cortex represents learned rules for categorization ↗](https://doi.org/10.1038/s41586-021-03452-z)**Sandra Reinert, Mark Hübener, Tobias Bonhoeffer et al.*133 citations*
690. **[Omicron likely to weaken COVID vaccine protection ↗](https://doi.org/10.1038/d41586-021-03672-3)**Ewen Callaway*133 citations*
691. **[Allometric rules for mammalian cortical layer 5 neuron biophysics ↗](https://doi.org/10.1038/s41586-021-04072-3)**Lou Beaulieu-Laroche, Norma J. Brown, Marissa Hansen et al.*132 citations*
692. **[Fast-spreading COVID variant can elude immune responses ↗](https://doi.org/10.1038/d41586-021-00121-z)**Ewen Callaway*132 citations*
693. **[The COVID lab-leak hypothesis: what scientists do and don’t know ↗](https://doi.org/10.1038/d41586-021-01529-3)**Amy Maxmen, Smriti Mallapaty*132 citations*
694. **[VLDLR and ApoER2 are receptors for multiple alphaviruses ↗](https://doi.org/10.1038/s41586-021-04326-0)**Lars E. Clark, Sarah A. Clark, ChieYu Lin et al.*132 citations*
695. **[Make electric vehicles lighter to maximize climate and safety benefits ↗](https://doi.org/10.1038/d41586-021-02760-8)**Blake Shaffer, Maximilian Auffhammer, Constantine Samaras*131 citations*
696. **[Meaningful measures of human society in the twenty-first century ↗](https://doi.org/10.1038/s41586-021-03660-7)**David M. J. Lazer, Eszter Hargittai, Deen Freelon et al.*131 citations*
697. **[Chromatic periodic activity down to 120 megahertz in a fast radio burst ↗](https://doi.org/10.1038/s41586-021-03724-8)**Inés Pastor-Marazuela, Liam Connor, Joeri van Leeuwen et al.*130 citations*
698. **[Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave ↗](https://doi.org/10.1038/s41586-021-04130-w)**Jessica T. Davis, Matteo Chinazzi, Nicola Perra et al.*130 citations*
699. **[A multilayered immune system through the lens of unconventional T cells ↗](https://doi.org/10.1038/s41586-021-03578-0)**Toufic Mayassi, Luis Bruno Barreiro, Jamie Rossjohn et al.*129 citations*
700. **[Design of biologically active binary protein 2D materials ↗](https://doi.org/10.1038/s41586-020-03120-8)**Ariel J. Ben‐Sasson, Joseph L. Watson, William Sheffler et al.*129 citations*

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