---
title: "Nature 2021 — all accepted papers, page 8 — the most cited first"
description: "All 3,641 papers of Nature 2021 · page 8 of 37, the most cited first; those with our summary link to it."
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# Nature 2021: all accepted papers

3,641 papers · page 8 of 37 · the most cited first · [← Nature 2021](https://md.research.elamur.ai/free/en/venues/nature/2021/)

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701. **[Structural insights into Ubr1-mediated N-degron polyubiquitination ↗](https://doi.org/10.1038/s41586-021-04097-8)**Man Pan, Qingyun Zheng, Tian Wang et al.*129 citations*
702. **[Widespread six degrees Celsius cooling on land during the Last Glacial Maximum ↗](https://doi.org/10.1038/s41586-021-03467-6)**Alan Seltzer, Jessica Ng, Werner Aeschbach et al.*129 citations*
703. **[Cleaving arene rings for acyclic alkenylnitrile synthesis ↗](https://doi.org/10.1038/s41586-021-03801-y)**Xu Qiu, Yueqian Sang, Hao Wu et al.*128 citations*
704. **[Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling ↗](https://doi.org/10.1038/s41586-021-03845-0)**Stephen X. Zhang, Andrew Lutas, Shang Yang et al.*128 citations*
705. **[Structures of human mGlu2 and mGlu7 homo- and heterodimers ↗](https://doi.org/10.1038/s41586-021-03641-w)**Juan Du, Dejian Wang, Hongcheng Fan et al.*128 citations*
706. **[Local circuit amplification of spatial selectivity in the hippocampus ↗](https://doi.org/10.1038/s41586-021-04169-9)**Tristan C. Geiller, Sadra Sadeh, Sebastian V. Rolotti et al.*127 citations*
707. **[Thalamic circuits for independent control of prefrontal signal and noise ↗](https://doi.org/10.1038/s41586-021-04056-3)**Arghya Mukherjee, Norman H. Lam, Ralf D. Wimmer et al.*127 citations*
708. **[In silico saturation mutagenesis of cancer genes ↗](https://doi.org/10.1038/s41586-021-03771-1)**Ferran Muiños, Francisco Martínez-Jiménez, Oriol Pich et al.*126 citations*
709. **[Oestrogen engages brain MC4R signalling to drive physical activity in female mice ↗](https://doi.org/10.1038/s41586-021-04010-3)**William C. Krause, Rubén Rodríguez, Bruno Gegenhuber et al.*126 citations*
710. **[Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine ↗](https://doi.org/10.1038/s41586-021-04231-6)**Makda S. Gebre, Susanne Rauch, Nicole Roth et al.*126 citations*
711. **[Giant modulation of optical nonlinearity by Floquet engineering ↗](https://doi.org/10.1038/s41586-021-04051-8)**Jun-Yi Shan, M. Ye, Hao Chu et al.*125 citations*
712. **[Mobility gradients yield rubbery surfaces on top of polymer glasses ↗](https://doi.org/10.1038/s41586-021-03733-7)**Zhiwei Hao, Asieh Ghanekarade, Ningtao Zhu et al.*125 citations*
713. **[Superspreading drives the COVID pandemic — and could help to tame it ↗](https://doi.org/10.1038/d41586-021-00460-x)**Dyani Lewis*125 citations*
714. **[The NIH Somatic Cell Genome Editing program ↗](https://doi.org/10.1038/s41586-021-03191-1)**Krishanu Saha, Erik J. Sontheimer, Philip John Brooks et al.*125 citations*
715. **[A quantum magnetic analogue to the critical point of water ↗](https://doi.org/10.1038/s41586-021-03411-8)**Julio Larrea Jiménez, S. P. G. Crone, Ellen Fogh et al.*124 citations*
716. **[Brazil is in water crisis — it needs a drought plan ↗](https://doi.org/10.1038/d41586-021-03625-w)**Augusto Getirana, Renata Libonati, Márcio Cataldi*124 citations*
717. **[How gut microbes could drive brain disorders ↗](https://doi.org/10.1038/d41586-021-00260-3)**Cassandra Willyard*124 citations*
718. **[Paths and timings of the peopling of Polynesia inferred from genomic networks ↗](https://doi.org/10.1038/s41586-021-03902-8)**Alexander G. Ioannidis, Javier Blanco-Portillo, Karla Sandoval et al.*124 citations*
719. **[Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit ↗](https://doi.org/10.1038/s41586-021-03522-2)**Boram Kim, Makoto I. Kanai, Yangkyun Oh et al.*124 citations*
720. **[Top climate scientists are sceptical that nations will rein in global warming ↗](https://doi.org/10.1038/d41586-021-02990-w)**Jeff Tollefson*124 citations*
721. **[Tracing the origin of hair follicle stem cells ↗](https://doi.org/10.1038/s41586-021-03638-5)**Ritsuko Morita, Noriko Sanzen, Hiroko Sasaki et al.*124 citations*
722. **[COVID vaccine immunity is waning — how much does that matter? ↗](https://doi.org/10.1038/d41586-021-02532-4)**Elie Dolgin*123 citations*
723. **[How severe are Omicron infections? ↗](https://doi.org/10.1038/d41586-021-03794-8)**Heidi K. Ledford*123 citations*
724. **[Incoherent transport across the strange-metal regime of overdoped cuprates ↗](https://doi.org/10.1038/s41586-021-03622-z)**J. Ayres, Maarten Berben, Matija Čulo et al.*123 citations*
725. **[The 13CO-rich atmosphere of a young accreting super-Jupiter ↗](https://doi.org/10.1038/s41586-021-03616-x)**Yapeng Zhang, Ignas A. G. Snellen, Alexander J. Bohn et al.*123 citations*
726. **[‘I hope you die’: how the COVID pandemic unleashed attacks on scientists ↗](https://doi.org/10.1038/d41586-021-02741-x)**Bianca Nogrady*123 citations*
727. **[AKIRIN2 controls the nuclear import of proteasomes in vertebrates ↗](https://doi.org/10.1038/s41586-021-04035-8)**Melanie de Almeida, Matthias Hinterndorfer, Hanna L. Brunner et al.*122 citations*
728. **[Directed assembly of layered perovskite heterostructures as single crystals ↗](https://doi.org/10.1038/s41586-021-03810-x)**Michael L. Aubrey, Abraham Saldivar Valdes, Marina Rucsandra Filip et al.*122 citations*
729. **[Genetic and epigenetic coordination of cortical interneuron development ↗](https://doi.org/10.1038/s41586-021-03933-1)**Kathryn C. Allaway, Mariano I. Gabitto, Orly L. Wapinski et al.*122 citations*
730. **[Decoding and perturbing decision states in real time ↗](https://doi.org/10.1038/s41586-020-03181-9)**Diogo Peixoto, Jessica R. Verhein, Roozbeh Kiani et al.*121 citations*
731. **[In situ mapping identifies distinct vascular niches for myelopoiesis ↗](https://doi.org/10.1038/s41586-021-03201-2)**Jizhou Zhang, Qingqing Wu, Courtney B. Johnson et al.*121 citations*
732. **[Tissues, not blood, are where immune cells function ↗](https://doi.org/10.1038/d41586-021-01396-y)**Donna L. Färber*121 citations*
733. **[Universal nomenclature for oxytocin–vasotocin ligand and receptor families ↗](https://doi.org/10.1038/s41586-020-03040-7)**Constantina Theofanopoulou, Gregory L. Gedman, James A. Cahill et al.*121 citations*
734. **[A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology ↗](https://doi.org/10.1038/s41586-021-03185-z)**Jinhong Wie, Zhenjiang Liu, Haikun Song et al.*120 citations*
735. **[All-sky dynamical response of the Galactic halo to the Large Magellanic Cloud ↗](https://doi.org/10.1038/s41586-021-03385-7)**Charlie Conroy, Rohan P. Naidu, Nicolás Garavito-Camargo et al.*120 citations*
736. **[Concerns about reported harvests in European forests ↗](https://doi.org/10.1038/s41586-021-03292-x)**Marc Palahí, Rubén Valbuena, Cornelius Senf et al.*120 citations*
737. **[Activation and disruption of a neural mechanism for novel choice in monkeys ↗](https://doi.org/10.1038/s41586-020-03115-5)**Alessandro Bongioanni, Davide Folloni, Lennart Verhagen et al.*119 citations*
738. **[Fizeau drag in graphene plasmonics ↗](https://doi.org/10.1038/s41586-021-03640-x)**Yinan Dong, Lin Xiong, Isabelle Phinney et al.*119 citations*
739. **[How COVID vaccines shaped 2021 in eight powerful charts ↗](https://doi.org/10.1038/d41586-021-03686-x)**Smriti Mallapaty, Ewen Callaway, Max Kozlov et al.*119 citations*
740. **[Multiview confocal super-resolution microscopy ↗](https://doi.org/10.1038/s41586-021-04110-0)**Yicong Wu, Xiaofei Han, Yijun P. Su et al.*119 citations*
741. **[Developmental and biophysical determinants of grass leaf size worldwide ↗](https://doi.org/10.1038/s41586-021-03370-0)**Alec S. Baird, Samuel H. Taylor, Jessica Pasquet‐Kok et al.*117 citations*
742. **[Electronic skin: from flexibility to a sense of touch ↗](https://doi.org/10.1038/d41586-021-00739-z)**Katharine Sanderson*117 citations*
743. **[Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator ↗](https://doi.org/10.1038/s41586-021-03208-9)**Lila Allou, Sara Balzano, Andreas Magg et al.*117 citations*
744. **[Selective sulfidation of metal compounds ↗](https://doi.org/10.1038/s41586-021-04321-5)**Caspar Stinn, Antoine Allanore*117 citations*
745. **[Terrestrial-type nitrogen-fixing symbiosis between seagrass and a marine bacterium ↗](https://doi.org/10.1038/s41586-021-04063-4)**Wiebke Mohr, Nadine Lehnen, Soeren Ahmerkamp et al.*117 citations*
746. **[5-HT modulation of a medial septal circuit tunes social memory stability ↗](https://doi.org/10.1038/s41586-021-03956-8)**Xiaoting Wu, Wade Morishita, Kevin Thomas Beier et al.*116 citations*
747. **[A multi-scale brain map derived from whole-brain volumetric reconstructions ↗](https://doi.org/10.1038/s41586-021-03284-x)**Christopher A. Brittin, Steven J. Cook, David H. Hall et al.*116 citations*
748. **[Host immunomodulatory lipids created by symbionts from dietary amino acids ↗](https://doi.org/10.1038/s41586-021-04083-0)**Sungwhan F. Oh, T. Praveena, Heebum Song et al.*116 citations*
749. **[A highly magnetized and rapidly rotating white dwarf as small as the Moon ↗](https://doi.org/10.1038/s41586-021-03615-y)**Ilaria Caiazzo, Kevin B. Burdge, Jim Fuller et al.*115 citations*
750. **[A lysine–cysteine redox switch with an NOS bridge regulates enzyme function ↗](https://doi.org/10.1038/s41586-021-03513-3)**Marie Wensien, Fabian Rabe von Pappenheim, Lisa-Marie Funk et al.*115 citations*
751. **[Angular momentum generation in nuclear fission ↗](https://doi.org/10.1038/s41586-021-03304-w)**Jonathan N. Wilson, D. Thisse, M. Lebois et al.*115 citations*
752. **[Experimental evidence for recovery of mercury-contaminated fish populations ↗](https://doi.org/10.1038/s41586-021-04222-7)**Paul J. Blanchfield, John W. M. Rudd, Lee E. Hrenchuk et al.*115 citations*
753. **[Intercalated amygdala clusters orchestrate a switch in fear state ↗](https://doi.org/10.1038/s41586-021-03593-1)**Kenta M. Hagihara, Olena Bukalo, Martin Zeller et al.*115 citations*
754. **[Superior robustness of anomalous non-reciprocal topological edge states ↗](https://doi.org/10.1038/s41586-021-03868-7)**Zhe Zhang, Pierre Delplace, Romain Fleury*115 citations*
755. **[Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity ↗](https://doi.org/10.1038/s41586-021-03684-z)**Agnes Mwakingwe-Omari, Sara A. Healy, Jacquelyn Lane et al.*115 citations*
756. **[A conserved mechanism for regulating replisome disassembly in eukaryotes ↗](https://doi.org/10.1038/s41586-021-04145-3)**Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris et al.*114 citations*
757. **[A decline in global CFC-11 emissions during 2018−2019 ↗](https://doi.org/10.1038/s41586-021-03260-5)**S. A. Montzka, G. S. Dutton, R. W. Portmann et al.*114 citations*
758. **[Astrocytes close a motor circuit critical period ↗](https://doi.org/10.1038/s41586-021-03441-2)**Sarah D. Ackerman, Nelson A. Perez-Catalan, Marc R. Freeman et al.*114 citations*
759. **[Meaningful collaborations can end ‘helicopter research’ ↗](https://doi.org/10.1038/d41586-021-01795-1)**María Fernanda Adame*114 citations*
760. **[Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV ↗](https://doi.org/10.1038/s41586-021-03927-z)**Irene Vercellino, Leonid A. Sazanov*114 citations*
761. **[Anaerobic endosymbiont generates energy for ciliate host by denitrification ↗](https://doi.org/10.1038/s41586-021-03297-6)**Jon S. Graf, Sina Schorn, Katharina Kitzinger et al.*113 citations*
762. **[Fast odour dynamics are encoded in the olfactory system and guide behaviour ↗](https://doi.org/10.1038/s41586-021-03514-2)**Tobias Ackels, Andrew Erskine, Debanjan Dasgupta et al.*113 citations*
763. **[Food systems: seven priorities to end hunger and protect the planet ↗](https://doi.org/10.1038/d41586-021-02331-x)**Joachim von Braun, Kaosar Afsana, L.O. Fresco et al.*113 citations*
764. **[Observation of universal ageing dynamics in antibiotic persistence ↗](https://doi.org/10.1038/s41586-021-04114-w)**Yoav Kaplan, Shaked Reich, Elyaqim Oster et al.*113 citations*
765. **[Structures of full-length glycoprotein hormone receptor signalling complexes ↗](https://doi.org/10.1038/s41586-021-03924-2)**Jia Duan, Peiyu Xu, Xi Cheng et al.*113 citations*
766. **[A crystalline tri-thorium cluster with σ-aromatic metal–metal bonding ↗](https://doi.org/10.1038/s41586-021-03888-3)**Josef T. Boronski, John A. Seed, David Hunger et al.*112 citations*
767. **[Chronic social isolation signals starvation and reduces sleep in Drosophila ↗](https://doi.org/10.1038/s41586-021-03837-0)**Wanhe Li, Zikun Wang, Sheyum Syed et al.*112 citations*
768. **[Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma ↗](https://doi.org/10.1038/s41586-021-03747-1)**Davide G. Berta, Heli Kuisma, Niko Välimäki et al.*112 citations*
769. **[Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition ↗](https://doi.org/10.1038/s41586-021-03540-0)**Jie Yu, Prashant Rao, Sarah Clark et al.*112 citations*
770. **[Structural basis for piRNA targeting ↗](https://doi.org/10.1038/s41586-021-03856-x)**Todd A. Anzelon, Saikat Chowdhury, Siobhan M. Hughes et al.*112 citations*
771. **[An elastic metal–organic crystal with a densely catenated backbone ↗](https://doi.org/10.1038/s41586-021-03880-x)**Wenjing Meng, Shun Kondo, Takuji Ito et al.*111 citations*
772. **[CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity ↗](https://doi.org/10.1038/s41586-021-04109-7)**Lingyun Long, Jun Wei, Seon Ah Lim et al.*111 citations*
773. **[Organelle degradation in the lens by PLAAT phospholipases ↗](https://doi.org/10.1038/s41586-021-03439-w)**Hideaki Morishita, Tomoya Eguchi, Satoshi Tsukamoto et al.*111 citations*
774. **[Structural basis of GABAB receptor–Gi protein coupling ↗](https://doi.org/10.1038/s41586-021-03507-1)**Cangsong Shen, Chunyou Mao, Chanjuan Xu et al.*111 citations*
775. **[The data-driven future of high-energy-density physics ↗](https://doi.org/10.1038/s41586-021-03382-w)**Peter Hatfield, Jim Gaffney, Gemma J. Anderson et al.*111 citations*
776. **[Tracing oncogene-driven remodelling of the intestinal stem cell niche ↗](https://doi.org/10.1038/s41586-021-03605-0)**Min Kyu Yum, Seungmin Han, Juergen Fink et al.*111 citations*
777. **[Concerns about phytoplankton bloom trends in global lakes ↗](https://doi.org/10.1038/s41586-021-03254-3)**Lian Feng, Yanhui Dai, Xuejiao Hou et al.*110 citations*
778. **[Locally ordered representation of 3D space in the entorhinal cortex ↗](https://doi.org/10.1038/s41586-021-03783-x)**Gily Ginosar, Johnatan Aljadeff, Yoram Burak et al.*110 citations*
779. **[Structures of mammalian RNA polymerase II pre-initiation complexes ↗](https://doi.org/10.1038/s41586-021-03554-8)**Shintaro Aibara, S. Schilbach, Patrick Cramer*110 citations*
780. **[Alarming COVID variants show vital role of genomic surveillance ↗](https://doi.org/10.1038/d41586-021-00065-4)**David Cyranoski*109 citations*
781. **[COVID vaccine boosters: the most important questions ↗](https://doi.org/10.1038/d41586-021-02158-6)**Ewen Callaway*109 citations*
782. **[Genomic reconstruction of the SARS-CoV-2 epidemic in England ↗](https://doi.org/10.1038/s41586-021-04069-y)**Harald S. Vöhringer, Theo Sanderson, Matthew Sinnott et al.*109 citations*
783. **[Microbes exploit death-induced nutrient release by gut epithelial cells ↗](https://doi.org/10.1038/s41586-021-03785-9)**Christopher J. Anderson, Christopher B. Medina, Brady J. Barron et al.*109 citations*
784. **[Multiple hominin dispersals into Southwest Asia over the past 400,000 years ↗](https://doi.org/10.1038/s41586-021-03863-y)**Huw S. Groucutt, Tom S. White, Eleanor M. L. Scerri et al.*109 citations*
785. **[The Card1 nuclease provides defence during type III CRISPR immunity ↗](https://doi.org/10.1038/s41586-021-03206-x)**Jakob T. Rostøl, Wei Xie, Vitaly Kuryavyi et al.*109 citations*
786. **[A metabolic function of the hippocampal sharp wave-ripple ↗](https://doi.org/10.1038/s41586-021-03811-w)**David Tingley, Kathryn McClain, Ekin Kaya et al.*108 citations*
787. **[Earliest known human burial in Africa ↗](https://doi.org/10.1038/s41586-021-03457-8)**María Martinón‐Torres, Francesco d’Errico, Elena Santos et al.*108 citations*
788. **[A functional map for diverse forelimb actions within brainstem circuitry ↗](https://doi.org/10.1038/s41586-020-03080-z)**Ludwig Ruder, Riccardo Schina, Harsh Kanodia et al.*107 citations*
789. **[DNA-driven condensation assembles the meiotic DNA break machinery ↗](https://doi.org/10.1038/s41586-021-03374-w)**Corentin Claeys Bouuaert, Stephen Pu, Juncheng Wang et al.*107 citations*
790. **[Fertilized egg cells secrete endopeptidases to avoid polytubey ↗](https://doi.org/10.1038/s41586-021-03387-5)**Xiaobo Yu, Xuecheng Zhang, Peng Zhao et al.*107 citations*
791. **[Linear-in temperature resistivity from an isotropic Planckian scattering rate ↗](https://doi.org/10.1038/s41586-021-03697-8)**G. Grissonnanche, Yawen Fang, Anaëlle Legros et al.*107 citations*
792. **[Novavax offers first evidence that COVID vaccines protect people against variants ↗](https://doi.org/10.1038/d41586-021-00268-9)**Ewen Callaway, Smriti Mallapaty*107 citations*
793. **[Single-neuronal predictions of others’ beliefs in humans ↗](https://doi.org/10.1038/s41586-021-03184-0)**Mohsen Jamali, Benjamin L. Grannan, Evelina G. Fedorenko et al.*107 citations*
794. **[Approaching the intrinsic exciton physics limit in two-dimensional semiconductor diodes ↗](https://doi.org/10.1038/s41586-021-03949-7)**Peng Chen, Timothy L. Atallah, Zhaoyang Lin et al.*106 citations*
795. **[Lenghu on the Tibetan Plateau as an astronomical observing site ↗](https://doi.org/10.1038/s41586-021-03711-z)**Licai Deng, Fan Yang, Xiaodian Chen et al.*106 citations*
796. **[Plume-driven recratonization of deep continental lithospheric mantle ↗](https://doi.org/10.1038/s41586-021-03395-5)**Jingao Liu, David Graham Pearson, Lawrence Hongliang Wang et al.*106 citations*
797. **[Structure and mechanism of blood–brain-barrier lipid transporter MFSD2A ↗](https://doi.org/10.1038/s41586-021-03782-y)**Chase A. P. Wood, Jinru Zhang, Deniz Aydın et al.*106 citations*
798. **[MARK4 controls ischaemic heart failure through microtubule detyrosination ↗](https://doi.org/10.1038/s41586-021-03573-5)**Xianjun Yu, Xiao Chen, Mamta Amrute‐Nayak et al.*105 citations*
799. **[Mitochondrial sorting and assembly machinery operates by β-barrel switching ↗](https://doi.org/10.1038/s41586-020-03113-7)**Hironori Takeda, Akihisa Tsutsumi, Tomohiro Nishizawa et al.*105 citations*
800. **[Robo-writers: the rise and risks of language-generating AI ↗](https://doi.org/10.1038/d41586-021-00530-0)**Matthew Hutson*105 citations*

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