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title: "Nature 2022 — all accepted papers, page 2 — the most cited first"
description: "All 3,983 papers of Nature 2022 · page 2 of 40, the most cited first; those with our summary link to it."
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# Nature 2022: all accepted papers

3,983 papers · page 2 of 40 · the most cited first · [← Nature 2022](https://md.research.elamur.ai/free/en/venues/nature/2022/)

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101. **[APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes ↗](https://doi.org/10.1038/s41586-022-05439-w)**Joel Blanchard, Leyla Anne Akay, José Dávila-Velderrain et al.*483 citations*
102. **[A gut-derived metabolite alters brain activity and anxiety behaviour in mice ↗](https://doi.org/10.1038/s41586-022-04396-8)**Brittany D. Needham, Masanori Funabashi, Mark D. Adame et al.*482 citations*
103. **[Time-reversal symmetry-breaking charge order in a kagome superconductor ↗](https://doi.org/10.1038/s41586-021-04327-z)**Charles Hillis Mielke III, Debarchan Das, Jia‐Xin Yin et al.*482 citations*
104. **[High-brightness all-polymer stretchable LED with charge-trapping dilution ↗](https://doi.org/10.1038/s41586-022-04400-1)**Zhitao Zhang, Weichen Wang, Yuanwen Jiang et al.*481 citations*
105. **[Hydroxamic acid pre-adsorption raises the efficiency of cosensitized solar cells ↗](https://doi.org/10.1038/s41586-022-05460-z)**Yameng Ren, Dan Zhang, Jiajia Suo et al.*481 citations*
106. **[Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir ↗](https://doi.org/10.1038/s41586-022-05514-2)**Sho Iketani, Hiroshi Mohri, Bruce Culbertson et al.*480 citations*
107. **[Progress and prospects in magnetic topological materials ↗](https://doi.org/10.1038/s41586-021-04105-x)**Bogdan Andrei Bernevig, Claudia Felser, Haim Beidenkopf*480 citations*
108. **[Somatic mutation rates scale with lifespan across mammals ↗](https://doi.org/10.1038/s41586-022-04618-z)**Alex Cagan, Adrian Baez‐Ortega, Natalia Brzozowska et al.*478 citations*
109. **[A microbial supply chain for production of the anti-cancer drug vinblastine ↗](https://doi.org/10.1038/s41586-022-05157-3)**Jie Zhang, Lea G. Hansen, Olga Gudich et al.*476 citations*
110. **[Genetic diversity fuels gene discovery for tobacco and alcohol use ↗](https://doi.org/10.1038/s41586-022-05477-4)**Gretchen Saunders, Xingyan Wang, Fang Chen et al.*476 citations*
111. **[Discovering faster matrix multiplication algorithms with reinforcement learning ↗](https://doi.org/10.1038/s41586-022-05172-4)**Alhussein Fawzi, Matej Balog, Aja Huang et al.*475 citations*
112. **[Structures of α-synuclein filaments from human brains with Lewy pathology ↗](https://doi.org/10.1038/s41586-022-05319-3)**Yang Yang, Yang Shi, Manuel Schweighauser et al.*475 citations*
113. **[Fast universal quantum gate above the fault-tolerance threshold in silicon ↗](https://doi.org/10.1038/s41586-021-04182-y)**Akito Noiri, Kenta Takeda, Takashi Nakajima et al.*472 citations*
114. **[Uniform nucleation and epitaxy of bilayer molybdenum disulfide on sapphire ↗](https://doi.org/10.1038/s41586-022-04523-5)**Lei Liu, Taotao Li, Liang Ma et al.*472 citations*
115. **[Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes ↗](https://doi.org/10.1038/s41586-022-05388-4)**Teh‐Wei Wang, Yoshikazu Johmura, Narumi Suzuki et al.*471 citations*
116. **[Effective drug combinations in breast, colon and pancreatic cancer cells ↗](https://doi.org/10.1038/s41586-022-04437-2)**Patricia Jaaks, Elizabeth A. Coker, Daniël J. Vis et al.*465 citations*
117. **[Single-cell roadmap of human gonadal development ↗](https://doi.org/10.1038/s41586-022-04918-4)**Luz García‐Alonso, Valentina Lorenzi, Cecilia Icoresi-Mazzeo et al.*465 citations*
118. **[Strain-retardant coherent perovskite phase stabilized Ni-rich cathode ↗](https://doi.org/10.1038/s41586-022-05238-3)**Liguang Wang, Tongchao Liu, Tianpin Wu et al.*464 citations*
119. **[Intermolecular 2π+2σ-photocycloaddition enabled by triplet energy transfer ↗](https://doi.org/10.1038/s41586-022-04636-x)**Roman Kleinmans, Tobias Pinkert, Subhabrata Dutta et al.*455 citations*
120. **[Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron ↗](https://doi.org/10.1038/s41586-022-04465-y)**Jinyan Liu, Abishek Chandrashekar, Daniel Sellers et al.*451 citations*
121. **[Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer ↗](https://doi.org/10.1038/s41586-022-04508-4)**Kohei Shitara, Jaffer A. Ajani, Markus Hermann Moehler et al.*449 citations*
122. **[Asymmetric pore windows in MOF membranes for natural gas valorization ↗](https://doi.org/10.1038/s41586-022-04763-5)**Sheng Zhou, Osama Shekhah, Adrián Ramírez et al.*448 citations*
123. **[Electroreduction of nitrogen with almost 100% current-to-ammonia efficiency ↗](https://doi.org/10.1038/s41586-022-05108-y)**Hoang‐Long Du, Manjunath Chatti, Rebecca Y. Hodgetts et al.*448 citations*
124. **[Two-dimensional materials prospects for non-volatile spintronic memories ↗](https://doi.org/10.1038/s41586-022-04768-0)**Hyunsoo Yang, Sergio O. Valenzuela, Mairbek Chshiev et al.*447 citations*
125. **[Global trends of cropland phosphorus use and sustainability challenges ↗](https://doi.org/10.1038/s41586-022-05220-z)**Tan Zou, Xin Zhang, Eric A. Davidson*446 citations*
126. **[Resolving the gravitational redshift across a millimetre-scale atomic sample ↗](https://doi.org/10.1038/s41586-021-04349-7)**Tobias Bothwell, Colin J. Kennedy, Alexander Aeppli et al.*446 citations*
127. **[The sequences of 150,119 genomes in the UK Biobank ↗](https://doi.org/10.1038/s41586-022-04965-x)**Bjarni V. Halldórsson, Hannes P. Eggertsson, Kristjan H. S. Moore et al.*445 citations*
128. **[A tissue-like neurotransmitter sensor for the brain and gut ↗](https://doi.org/10.1038/s41586-022-04615-2)**Jinxing Li, Yuxin Liu, Lei Yuan et al.*443 citations*
129. **[Charge-density-wave-driven electronic nematicity in a kagome superconductor ↗](https://doi.org/10.1038/s41586-022-04493-8)**Linpeng Nie, Kuanglv Sun, Wanru Ma et al.*438 citations*
130. **[Microcomb-driven silicon photonic systems ↗](https://doi.org/10.1038/s41586-022-04579-3)**Haowen Shu, Lin Chang, Yuansheng Tao et al.*437 citations*
131. **[Autism genes converge on asynchronous development of shared neuron classes ↗](https://doi.org/10.1038/s41586-021-04358-6)**Bruna da Silveira Paulsen, Silvia Velasco, Amanda J. Kedaigle et al.*433 citations*
132. **[A large-scale microelectromechanical-systems-based silicon photonics LiDAR ↗](https://doi.org/10.1038/s41586-022-04415-8)**Xiaosheng Zhang, Kyungmok Kwon, Johannes Henriksson et al.*432 citations*
133. **[Women are credited less in science than men ↗](https://doi.org/10.1038/s41586-022-04966-w)**Matthew B. Ross, Britta M. Glennon, Raviv Murciano-Goroff et al.*432 citations*
134. **[A global reptile assessment highlights shared conservation needs of tetrapods ↗](https://doi.org/10.1038/s41586-022-04664-7)**Neil A. Cox, Bruce E. Young, Philip Bowles et al.*428 citations*
135. **[LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity ↗](https://doi.org/10.1038/s41586-022-05272-1)**Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai et al.*428 citations*
136. **[A portrait of the Higgs boson by the CMS experiment ten years after the discovery ↗](https://doi.org/10.1038/s41586-022-04892-x)**A. Tumasyan, W. Adam, J. W. Andrejkovic et al.*427 citations*
137. **[Perovskite–organic tandem solar cells with indium oxide interconnect ↗](https://doi.org/10.1038/s41586-022-04455-0)**Kai Oliver Brinkmann, Tim Becker, F. Zimmermann et al.*421 citations*
138. **[Toroidal topology of population activity in grid cells ↗](https://doi.org/10.1038/s41586-021-04268-7)**Richard J. Gardner, Erik Hermansen, Marius Pachitariu et al.*420 citations*
139. **[Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration ↗](https://doi.org/10.1038/s41586-022-05535-x)**Victoria Moiseeva, Andrés Cisneros, Valentina Sica et al.*416 citations*
140. **[ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis ↗](https://doi.org/10.1038/s41586-022-04753-7)**Ting Zhang, Chaoran Yin, Aleksandr Fedorov et al.*413 citations*
141. **[Extracellular fluid viscosity enhances cell migration and cancer dissemination ↗](https://doi.org/10.1038/s41586-022-05394-6)**Kaustav Bera, Alexander Kiepas, Inês Godet et al.*412 citations*
142. **[Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy ↗](https://doi.org/10.1038/s41586-022-04817-8)**Mark D. Chaffin, Irinna Papangeli, Bridget Simonson et al.*412 citations*
143. **[Nonlinear control of transcription through enhancer–promoter interactions ↗](https://doi.org/10.1038/s41586-022-04570-y)**Jessica Zuin, Grégory Roth, Yinxiu Zhan et al.*410 citations*
144. **[Spatial profiling of chromatin accessibility in mouse and human tissues ↗](https://doi.org/10.1038/s41586-022-05094-1)**Yanxiang Deng, Marek Bartošovič, Sai Ma et al.*410 citations*
145. **[Universal control of a six-qubit quantum processor in silicon ↗](https://doi.org/10.1038/s41586-022-05117-x)**Stephan G. J. Philips, Mateusz Tomasz Mądzik, Sergey V. Amitonov et al.*408 citations*
146. **[Akkermansia muciniphila phospholipid induces homeostatic immune responses ↗](https://doi.org/10.1038/s41586-022-04985-7)**Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu et al.*406 citations*
147. **[Revitalizing interface in protonic ceramic cells by acid etch ↗](https://doi.org/10.1038/s41586-022-04457-y)**Wenjuan Bian, Wei Wu, Baoming Wang et al.*404 citations*
148. **[From planetary to regional boundaries for agricultural nitrogen pollution ↗](https://doi.org/10.1038/s41586-022-05158-2)**Lena Schulte‐Uebbing, Arthur H. W. Beusen, Lex Bouwman et al.*399 citations*
149. **[A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery ↗](https://doi.org/10.1038/s41586-022-04893-w)**G. Aad, B. Abbott, D. C. Abbott et al.*398 citations*
150. **[Evidence for a single-layer van der Waals multiferroic ↗](https://doi.org/10.1038/s41586-021-04337-x)**Song Qian, Connor A. Occhialini, Emre Ergeçen et al.*396 citations*
151. **[Mutation bias reflects natural selection in Arabidopsis thaliana ↗](https://doi.org/10.1038/s41586-021-04269-6)**J. Grey Monroe, Thanvi Srikant, Pablo Carbonell-Bejerano et al.*396 citations*
152. **[The effect of rainfall changes on economic production ↗](https://doi.org/10.1038/s41586-021-04283-8)**Maximilian Kotz, Anders Levermann, Leonie Wenz*394 citations*
153. **[Androgen receptor activity in T cells limits checkpoint blockade efficacy ↗](https://doi.org/10.1038/s41586-022-04522-6)**Xiangnan Guan, Fanny Polesso, Chaojie Wang et al.*391 citations*
154. **[The field-free Josephson diode in a van der Waals heterostructure ↗](https://doi.org/10.1038/s41586-022-04504-8)**Heng Wu, Yaojia Wang, Yuanfeng Xu et al.*391 citations*
155. **[Chemical reprogramming of human somatic cells to pluripotent stem cells ↗](https://doi.org/10.1038/s41586-022-04593-5)**Jingyang Guan, Guan Wang, Jinlin Wang et al.*386 citations*
156. **[Biosynthetic potential of the global ocean microbiome ↗](https://doi.org/10.1038/s41586-022-04862-3)**Lucas Paoli, Hans‐Joachim Ruscheweyh, Clarissa C. Forneris et al.*384 citations*
157. **[A mechanically strong and ductile soft magnet with extremely low coercivity ↗](https://doi.org/10.1038/s41586-022-04935-3)**Liuliu Han, Fernando Maccari, Isnaldi Rodrigues de Souza Filho et al.*382 citations*
158. **[Virtual communication curbs creative idea generation ↗](https://doi.org/10.1038/s41586-022-04643-y)**Melanie S. Brucks, Jonathan Levav*380 citations*
159. **[The gut metabolite indole-3 propionate promotes nerve regeneration and repair ↗](https://doi.org/10.1038/s41586-022-04884-x)**Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica Chadwick et al.*378 citations*
160. **[Ultrathin ferroic HfO2–ZrO2 superlattice gate stack for advanced transistors ↗](https://doi.org/10.1038/s41586-022-04425-6)**Suraj Cheema, Nirmaan Shanker, Li‐Chen Wang et al.*374 citations*
161. **[High-κ perovskite membranes as insulators for two-dimensional transistors ↗](https://doi.org/10.1038/s41586-022-04588-2)**Jing‐Kai Huang, Yi Wan, Junjie Shi et al.*373 citations*
162. **[Single fibre enables acoustic fabrics via nanometre-scale vibrations ↗](https://doi.org/10.1038/s41586-022-04476-9)**Wei Qi Yan, Grace H. Noel, Gabriel Z. J. Loke et al.*373 citations*
163. **[The longitudinal dynamics and natural history of clonal haematopoiesis ↗](https://doi.org/10.1038/s41586-022-04785-z)**Margarete A. Fabre, José Guilherme de Almeida, Edoardo Fiorillo et al.*372 citations*
164. **[A phosphoinositide signalling pathway mediates rapid lysosomal repair ↗](https://doi.org/10.1038/s41586-022-05164-4)**Jay Xiaojun Tan, Toren Finkel*371 citations*
165. **[Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL ↗](https://doi.org/10.1038/s41586-022-05140-y)**Jiqin Zhang, Yongxian Hu, Jiaxuan Yang et al.*371 citations*
166. **[cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers ↗](https://doi.org/10.1038/s41586-022-04847-2)**Christy Hong, Michaël Schubert, Andréa E. Tijhuis et al.*371 citations*
167. **[Nociceptor neurons affect cancer immunosurveillance ↗](https://doi.org/10.1038/s41586-022-05374-w)**Mohammad Balood, Maryam Ahmadi, Tuany Eichwald et al.*369 citations*
168. **[Outracing champion Gran Turismo drivers with deep reinforcement learning ↗](https://doi.org/10.1038/s41586-021-04357-7)**Peter R. Wurman, Samuel Barrett, Kenta Kawamoto et al.*369 citations*
169. **[Genome evolution and diversity of wild and cultivated potatoes ↗](https://doi.org/10.1038/s41586-022-04822-x)**Dié Tang, Yuxin Jia, Jinzhe Zhang et al.*367 citations*
170. **[Human genetic and immunological determinants of critical COVID-19 pneumonia ↗](https://doi.org/10.1038/s41586-022-04447-0)**Qian Zhang, Paul Bastard, COVID Human Genetic Effort et al.*366 citations*
171. **[Hydrogen trapping and embrittlement in high-strength Al alloys ↗](https://doi.org/10.1038/s41586-021-04343-z)**Huan Zhao, Poulami Chakraborty, Dirk Ponge et al.*363 citations*
172. **[P-type electrical contacts for 2D transition-metal dichalcogenides ↗](https://doi.org/10.1038/s41586-022-05134-w)**Yan Wang, Jong Chan Kim, Yang Li et al.*360 citations*
173. **[A kilonova following a long-duration gamma-ray burst at 350 Mpc ↗](https://doi.org/10.1038/s41586-022-05390-w)**Jillian Rastinejad, Benjamin P. Gompertz, A. J. Levan et al.*358 citations*
174. **[Qubit teleportation between non-neighbouring nodes in a quantum network ↗](https://doi.org/10.1038/s41586-022-04697-y)**Sophie Hermans, Matteo Pompili, Hans K. C. Beukers et al.*356 citations*
175. **[T cells specific for α-myosin drive immunotherapy-related myocarditis ↗](https://doi.org/10.1038/s41586-022-05432-3)**Margaret L. Axelrod, Wouter C. Meijers, Elles M. Screever et al.*355 citations*
176. **[CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours ↗](https://doi.org/10.1038/s41586-022-04585-5)**Rebecca C. Larson, Michael C. Kann, Stefanie R. Bailey et al.*352 citations*
177. **[Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis ↗](https://doi.org/10.1038/s41586-021-04384-4)**Wanyan Deng, Yang Bai, Fan Deng et al.*348 citations*
178. **[STING-induced regulatory B cells compromise NK function in cancer immunity ↗](https://doi.org/10.1038/s41586-022-05254-3)**Sirui Li, Bhalchandra Mirlekar, Brandon M. Johnson et al.*347 citations*
179. **[Germinal centre-driven maturation of B cell response to mRNA vaccination ↗](https://doi.org/10.1038/s41586-022-04527-1)**Wooseob Kim, Julian Q. Zhou, Stephen C. Horvath et al.*345 citations*
180. **[Neoadjuvant relatlimab and nivolumab in resectable melanoma ↗](https://doi.org/10.1038/s41586-022-05368-8)**Rodabe Navroze Amaria, Michael Andrew Postow, Elizabeth M. Burton et al.*345 citations*
181. **[Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis ↗](https://doi.org/10.1038/s41586-022-05289-6)**Aveline A. Filliol, Yoshinobu Saito, Ajay Nair et al.*345 citations*
182. **[Human distal lung maps and lineage hierarchies reveal a bipotent progenitor ↗](https://doi.org/10.1038/s41586-022-04541-3)**Preetish Kadur Lakshminarasimha Murthy, Vishwaraj Sontake, Aleksandra Tata et al.*344 citations*
183. **[The road to fully programmable protein catalysis ↗](https://doi.org/10.1038/s41586-022-04456-z)**Sarah L. Lovelock, Rebecca Crawshaw, Sophie Basler et al.*343 citations*
184. **[A 2-million-year-old ecosystem in Greenland uncovered by environmental DNA ↗](https://doi.org/10.1038/s41586-022-05453-y)**Kurt Henrik Kjær, Mikkel Winther Pedersen, Bianca De Sanctis et al.*341 citations*
185. **[A function-based typology for Earth’s ecosystems ↗](https://doi.org/10.1038/s41586-022-05318-4)**David A. Keith, José Rafael Ferrer-Paris, Emily Nicholson et al.*340 citations*
186. **[YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING ↗](https://doi.org/10.1038/s41586-022-04924-6)**Hanna Lucie Sladitschek, Alberto Guarnieri, Giulia Brumana et al.*340 citations*
187. **[Aligned macrocycle pores in ultrathin films for accurate molecular sieving ↗](https://doi.org/10.1038/s41586-022-05032-1)**Zhiwei Jiang, Ruijiao Dong, Austin M. Evans et al.*339 citations*
188. **[Thermophotovoltaic efficiency of 40% ↗](https://doi.org/10.1038/s41586-022-04473-y)**Alina D. LaPotin, Kevin L. Schulte, Myles A. Steiner et al.*336 citations*
189. **[Au–Pd separation enhances bimetallic catalysis of alcohol oxidation ↗](https://doi.org/10.1038/s41586-022-04397-7)**Xiaoyang Jerry Huang, Ouardia Akdim, Mark Douthwaite et al.*334 citations*
190. **[Personalizing exoskeleton assistance while walking in the real world ↗](https://doi.org/10.1038/s41586-022-05191-1)**Patrick Slade, Mykel J. Kochenderfer, Scott L. Delp et al.*328 citations*
191. **[PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program ↗](https://doi.org/10.1038/s41586-022-05257-0)**Masao Hashimoto, Koichi Araki, Maria Andrea Cardenas et al.*326 citations*
192. **[Whole-genome sequencing reveals host factors underlying critical COVID-19 ↗](https://doi.org/10.1038/s41586-022-04576-6)**Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik et al.*326 citations*
193. **[FSH blockade improves cognition in mice with Alzheimer’s disease ↗](https://doi.org/10.1038/s41586-022-04463-0)**Jing Xiong, Seong Su Kang, Zhihao Wang et al.*324 citations*
194. **[Multi-environment robotic transitions through adaptive morphogenesis ↗](https://doi.org/10.1038/s41586-022-05188-w)**Robert L. Baines, Sree Kalyan Patiballa, Joran Booth et al.*324 citations*
195. **[Ovarian cancer mutational processes drive site-specific immune evasion ↗](https://doi.org/10.1038/s41586-022-05496-1)**Ignacio Vázquez-Garćıa, Florian Uhlitz, Nicholas Ceglia et al.*324 citations*
196. **[An exercise-inducible metabolite that suppresses feeding and obesity ↗](https://doi.org/10.1038/s41586-022-04828-5)**Veronica L. Li, Yang He, Kévin Contrepois et al.*323 citations*
197. **[Electrochemically driven cross-electrophile coupling of alkyl halides ↗](https://doi.org/10.1038/s41586-022-04540-4)**Wen Zhang, Lingxiang Lu, Wendy Zhang et al.*323 citations*
198. **[Human distal airways contain a multipotent secretory cell that can regenerate alveoli ↗](https://doi.org/10.1038/s41586-022-04552-0)**Maria Ciocca Basil, Fabian L. Cardenas‐Diaz, Jaymin J. Kathiriya et al.*322 citations*
199. **[Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes ↗](https://doi.org/10.1038/s41586-022-04754-6)**Sophia Maschalidi, Parul Mehrotra, Burcu Nur Keçeli et al.*322 citations*
200. **[The metastatic spread of breast cancer accelerates during sleep ↗](https://doi.org/10.1038/s41586-022-04875-y)**Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab et al.*320 citations*

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