---
title: "Science 2012 — all accepted papers — the most cited first"
description: "All 4,169 papers of Science 2012 · page 1 of 42, the most cited first; those with our summary link to it."
canonical: "https://research.elamur.ai/free/en/venues/science/2012/papers/"
---
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# Science 2012: all accepted papers

4,169 papers · page 1 of 42 · the most cited first · [← Science 2012](https://md.research.elamur.ai/free/en/venues/science/2012/)

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1. **[A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity ↗](https://doi.org/10.1126/science.1225829)**Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al.*17,051 citations*
2. **[Efficient Hybrid Solar Cells Based on Meso-Superstructured Organometal Halide Perovskites ↗](https://doi.org/10.1126/science.1228604)**Michael M. Lee, Joël Teuscher, Tsutomu Miyasaka et al.*10,668 citations*
3. **[Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway ↗](https://doi.org/10.1126/science.1232458)**Lijun Sun, Jiaxi Wu, Fenghe Du et al.*4,925 citations*
4. **[Host-Gut Microbiota Metabolic Interactions ↗](https://doi.org/10.1126/science.1223813)**Jeremy Kirk Nicholson, Elaine C. Holmes, James K. Kinross et al.*4,725 citations*
5. **[Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs ↗](https://doi.org/10.1126/science.1216210)**Lihong V. Wang, Song Hu*4,297 citations*
6. **[Interactions Between the Microbiota and the Immune System ↗](https://doi.org/10.1126/science.1223490)**Lora V. Hooper, Dan R. Littman, Andrew J. Macpherson*4,162 citations*
7. **[Signatures of Majorana Fermions in Hybrid Superconductor-Semiconductor Nanowire Devices ↗](https://doi.org/10.1126/science.1222360)**Vincent Mourik, K. Zuo, Sergey Frolov et al.*4,155 citations*
8. **[Spin-Torque Switching with the Giant Spin Hall Effect of Tantalum ↗](https://doi.org/10.1126/science.1218197)**Luqiao Liu, Chi‐Feng Pai, Y. Li et al.*4,108 citations*
9. **[Laser Scribing of High-Performance and Flexible Graphene-Based Electrochemical Capacitors ↗](https://doi.org/10.1126/science.1216744)**Maher F. El‐Kady, Veronica Strong, Sergey Dubin et al.*4,008 citations*
10. **[Functional Supramolecular Polymers ↗](https://doi.org/10.1126/science.1205962)**Takuzo Aida, Egbert W. Meijer, Samuel Isaac Stupp*3,696 citations*
11. **[Systematic Localization of Common Disease-Associated Variation in Regulatory DNA ↗](https://doi.org/10.1126/science.1222794)**Matthew T. Maurano, Richard Humbert, Eric Rynes et al.*3,692 citations*
12. **[Mitochondrial Fission, Fusion, and Stress ↗](https://doi.org/10.1126/science.1219855)**Richard J. Youle, Alexander M. van der Bliek*3,645 citations*
13. **[Unimpeded Permeation of Water Through Helium-Leak–Tight Graphene-Based Membranes ↗](https://doi.org/10.1126/science.1211694)**Rahul R. Nair, HengAn Wu, P. N. Jayaram et al.*3,073 citations*
14. **[The Active Site of Methanol Synthesis over Cu/ZnO/Al 2 O 3 Industrial Catalysts ↗](https://doi.org/10.1126/science.1219831)**Malte Behrens, Felix Studt, Igor Kasatkin et al.*2,670 citations*
15. **[A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells ↗](https://doi.org/10.1126/science.1219179)**Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro et al.*2,568 citations*
16. **[Field-Effect Tunneling Transistor Based on Vertical Graphene Heterostructures ↗](https://doi.org/10.1126/science.1218461)**L. Britnell, Roman Gorbachev, R. Jalil et al.*2,561 citations*
17. **[Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice ↗](https://doi.org/10.1126/science.1227157)**Kelvin C. Luk, Victoria M. Kehm, Jenna C. Carroll et al.*2,545 citations*
18. **[Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA ↗](https://doi.org/10.1126/science.1229963)**Jiaxi Wu, Lijun Sun, Xiang Chen et al.*2,541 citations*
19. **[Detecting Causality in Complex Ecosystems ↗](https://doi.org/10.1126/science.1227079)**George Sugihara, Robert Mccredie May, Hao Ye et al.*2,539 citations*
20. **[Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota ↗](https://doi.org/10.1126/science.1224820)**Janelle C. Arthur, Ernesto Peréz-Chanona, Marcus Mühlbauer et al.*2,251 citations*
21. **[The State and Fate of Himalayan Glaciers ↗](https://doi.org/10.1126/science.1215828)**Tobias Bolch, Anil Vishnupant Kulkarni, Andreas Kääb et al.*2,207 citations*
22. **[Anticipating Critical Transitions ↗](https://doi.org/10.1126/science.1225244)**Marten Scheffer, Stephen R. Carpenter, Timothy M. Lenton et al.*2,192 citations*
23. **[A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads ↗](https://doi.org/10.1126/science.1214081)**Shawn M. Douglas, Ido Bachelet, George McDonald Church*2,180 citations*
24. **[Valorization of Biomass: Deriving More Value from Waste ↗](https://doi.org/10.1126/science.1218930)**Christopher J. Tuck, Eduardo Pérez, István T. Horváth et al.*2,165 citations*
25. **[A Universal Method to Produce Low–Work Function Electrodes for Organic Electronics ↗](https://doi.org/10.1126/science.1218829)**Yinhua Zhou, Canek Fuentes‐Hernandez, Jaewon Shim et al.*2,140 citations*
26. **[Large-Pore Apertures in a Series of Metal-Organic Frameworks ↗](https://doi.org/10.1126/science.1220131)**Hexiang Deng, Sergio Grunder, Kyle E. Cordova et al.*2,126 citations*
27. **[Binary Interaction Dominates the Evolution of Massive Stars ↗](https://doi.org/10.1126/science.1223344)**Hugues Sana, S. E. de Mink, A. de Koter et al.*2,118 citations*
28. **[A High-Coverage Genome Sequence from an Archaic Denisovan Individual ↗](https://doi.org/10.1126/science.1224344)**Matthias Meyer, Martin Kircher, Marie-Theres Gansauge et al.*1,961 citations*
29. **[Hydrocarbon Separations in a Metal-Organic Framework with Open Iron(II) Coordination Sites ↗](https://doi.org/10.1126/science.1217544)**Eric D. Bloch, Wendy Lee Queen, Rajamani Krishna et al.*1,928 citations*
30. **[Designing Cell-Compatible Hydrogels for Biomedical Applications ↗](https://doi.org/10.1126/science.1214804)**Dror Seliktar*1,923 citations*
31. **[A Reversible and Higher-Rate Li-O 2 Battery ↗](https://doi.org/10.1126/science.1223985)**Zhangquan Peng, Stefan A. Freunberger, Yuhui Chen et al.*1,915 citations*
32. **[Conversion of Wastes into Bioelectricity and Chemicals by Using Microbial Electrochemical Technologies ↗](https://doi.org/10.1126/science.1217412)**Bruce E. Logan, Korneel Rabaey*1,877 citations*
33. **[Bright Coherent Ultrahigh Harmonics in the keV X-ray Regime from Mid-Infrared Femtosecond Lasers ↗](https://doi.org/10.1126/science.1218497)**Tenio Popmintchev, Ming-Chang Chen, Dimitar Popmintchev et al.*1,829 citations*
34. **[The Paleozoic Origin of Enzymatic Lignin Decomposition Reconstructed from 31 Fungal Genomes ↗](https://doi.org/10.1126/science.1221748)**Dimitrios Floudas, Manfred Binder, Robert W. Riley et al.*1,779 citations*
35. **[Linking Crystallographic Model and Data Quality ↗](https://doi.org/10.1126/science.1218231)**P. Andrew Karplus, Kay Diederichs*1,774 citations*
36. **[Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor ↗](https://doi.org/10.1126/science.1227166)**Tadahiro Shimazu, Matthew D. Hirschey, John Newman et al.*1,762 citations*
37. **[Plant Species Richness and Ecosystem Multifunctionality in Global Drylands ↗](https://doi.org/10.1126/science.1215442)**Fernando T. Maestre, José Luis Quero, Nicholas J. Gotelli et al.*1,718 citations*
38. **[Disease Tolerance as a Defense Strategy ↗](https://doi.org/10.1126/science.1214935)**Ruslan M. Medzhitov, David S. Schneider, Miguel Parreira Soares*1,702 citations*
39. **[The Protein-Folding Problem, 50 Years On ↗](https://doi.org/10.1126/science.1219021)**Ken A. Dill, Justin L. MacCallum*1,693 citations*
40. **[Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets ↗](https://doi.org/10.1126/science.1213362)**Sander Herfst, Eefje J. A. Schrauwen, Martin Linster et al.*1,665 citations*
41. **[Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function ↗](https://doi.org/10.1126/science.1219328)**Torsten Olszak, Dingding An, Sebastian Zeißig et al.*1,660 citations*
42. **[The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens ↗](https://doi.org/10.1126/science.1220761)**Kevin J. Forsberg, Alejandro Reyes, Bin Wang et al.*1,645 citations*
43. **[Synaptic Dysfunction in Depression: Potential Therapeutic Targets ↗](https://doi.org/10.1126/science.1222939)**Ronald S. Duman, George K. Aghajanian*1,637 citations*
44. **[Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes ↗](https://doi.org/10.1126/science.1219240)**Jacob Adam Tennessen, Abigail W. Bigham, Timothy D. O’Connor et al.*1,611 citations*
45. **[Isolated Metal Atom Geometries as a Strategy for Selective Heterogeneous Hydrogenations ↗](https://doi.org/10.1126/science.1215864)**Georgios Kyriakou, Matthew B. Boucher, April D. Jewell et al.*1,603 citations*
46. **[Some Consequences of Having Too Little ↗](https://doi.org/10.1126/science.1222426)**Anuj Shah, Sendhil Mullainathan, Eldar B. Shafir*1,551 citations*
47. **[A Reconciled Estimate of Ice-Sheet Mass Balance ↗](https://doi.org/10.1126/science.1228102)**Andrew P. Shepherd, Erik R. Ivins, A Geruo et al.*1,511 citations*
48. **[A Common Pesticide Decreases Foraging Success and Survival in Honey Bees ↗](https://doi.org/10.1126/science.1215039)**Mickaël Henry, Maxime Béguin, Fabrice Réquier et al.*1,474 citations*
49. **[Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals ↗](https://doi.org/10.1126/science.1226339)**Nobuya Koike, Seung Hee Yoo, Hung-Chung Huang et al.*1,458 citations*
50. **[The Application of Ecological Theory Toward an Understanding of the Human Microbiome ↗](https://doi.org/10.1126/science.1224203)**Elizabeth K. Costello, Keaton Stagaman, Les Dethlefsen et al.*1,437 citations*
51. **[Next-Generation Digital Information Storage in DNA ↗](https://doi.org/10.1126/science.1226355)**George McDonald Church, Yuan Gao, Sriram Kosuri*1,428 citations*
52. **[Substrate-Controlled Succession of Marine Bacterioplankton Populations Induced by a Phytoplankton Bloom ↗](https://doi.org/10.1126/science.1218344)**Hanno Teeling, Bernhard Maximilian Fuchs, Dörte Becher et al.*1,422 citations*
53. **[An Update of Wallace’s Zoogeographic Regions of the World ↗](https://doi.org/10.1126/science.1228282)**Ben G. Holt, Jean‐Philippe Lessard, Michael K. Borregaard et al.*1,414 citations*
54. **[Observation of Skyrmions in a Multiferroic Material ↗](https://doi.org/10.1126/science.1214143)**Shinichiro Seki, Xiuzhen Yu, Shintaro Ishiwata et al.*1,413 citations*
55. **[Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation ↗](https://doi.org/10.1126/science.1218595)**Mohit Jain, Roland Nilsson, Sonia Sharma et al.*1,401 citations*
56. **[Simultaneously Mitigating Near-Term Climate Change and Improving Human Health and Food Security ↗](https://doi.org/10.1126/science.1210026)**Drew T. Shindell, Johan C.I. Kuylenstierna, E. Vignati et al.*1,374 citations*
57. **[Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities ↗](https://doi.org/10.1126/science.1226338)**Zhiliang Cheng, Ajlan Al Zaki, James Z. Hui et al.*1,322 citations*
58. **[A Local Proton Source Enhances CO 2 Electroreduction to CO by a Molecular Fe Catalyst ↗](https://doi.org/10.1126/science.1224581)**Cyrille Costentin, Samuel Drouet, Marc Robert et al.*1,315 citations*
59. **[Neonicotinoid Pesticide Reduces Bumble Bee Colony Growth and Queen Production ↗](https://doi.org/10.1126/science.1215025)**Penelope R. Whitehorn, Stephanie O’Connor, FELIX L. WÄCKERS et al.*1,290 citations*
60. **[A Physically Transient Form of Silicon Electronics ↗](https://doi.org/10.1126/science.1226325)**Suk‐Won Hwang, Hu Tao, Dae‐Hyeong Kim et al.*1,277 citations*
61. **[A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes ↗](https://doi.org/10.1126/science.1215040)**Daniel G. MacArthur, Suganthi Balasubramanian, Adam Frankish et al.*1,270 citations*
62. **[Epigenetic Regulation by Long Noncoding RNAs ↗](https://doi.org/10.1126/science.1231776)**Jeannie T. Lee*1,259 citations*
63. **[Network Interventions ↗](https://doi.org/10.1126/science.1217330)**Thomas William Valente*1,248 citations*
64. **[The Diffusion of Microfinance ↗](https://doi.org/10.1126/science.1236498)**Abhijit Banerjee, Arun G. Chandrasekhar, Esther Duflo et al.*1,248 citations*
65. **[Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons ↗](https://doi.org/10.1126/science.1232251)**Ke Xu, Guisheng Zhong, Xiaowei Zhuang*1,246 citations*
66. **[Three-Dimensional Structures Self-Assembled from DNA Bricks ↗](https://doi.org/10.1126/science.1227268)**Yonggang Ke, Luvena L. Ong, William M. Shih et al.*1,246 citations*
67. **[Supported Iron Nanoparticles as Catalysts for Sustainable Production of Lower Olefins ↗](https://doi.org/10.1126/science.1215614)**Hirsa M. Torres Galvis, Johannes Hendrik Bitter, Chaitanya B. Khare et al.*1,244 citations*
68. **[Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders ↗](https://doi.org/10.1126/science.1227764)**Brian J. O’Roak, Laura Vives, Wenqing Fu et al.*1,237 citations*
69. **[A Molecular MoS 2 Edge Site Mimic for Catalytic Hydrogen Generation ↗](https://doi.org/10.1126/science.1215868)**Hemamala I. Karunadasa, E. Montalvo, Yujie Sun et al.*1,212 citations*
70. **[Female Leadership Raises Aspirations and Educational Attainment for Girls: A Policy Experiment in India ↗](https://doi.org/10.1126/science.1212382)**Lori A. Beaman, Esther Duflo, Rohini Pande et al.*1,205 citations*
71. **[Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity ↗](https://doi.org/10.1126/science.1215135)**Dudley W. Lamming, Lan Ye, Pekka Katajisto et al.*1,195 citations*
72. **[The Role of Driving Energy and Delocalized States for Charge Separation in Organic Semiconductors ↗](https://doi.org/10.1126/science.1217745)**Artem A. Bakulin, Akshay Rao, Vlad G. Pavelyev et al.*1,182 citations*
73. **[Unlike Bone, Cartilage Regeneration Remains Elusive ↗](https://doi.org/10.1126/science.1222454)**Daniel J. Huey, Jerry C. Y. Hu, Kyriacos A. Athanasiou*1,182 citations*
74. **[Lethally Hot Temperatures During the Early Triassic Greenhouse ↗](https://doi.org/10.1126/science.1224126)**Yadong Sun, Michael M. Joachimski, Paul B. Wignall et al.*1,175 citations*
75. **[Probing the Ultimate Limits of Plasmonic Enhancement ↗](https://doi.org/10.1126/science.1224823)**Cristian Ciracì, Ryan T. Hill, Jack J. Mock et al.*1,172 citations*
76. **[Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell ↗](https://doi.org/10.1126/science.1229164)**Chenghang Zong, Sijia Lü, Alec R. Chapman et al.*1,153 citations*
77. **[High-Resolution EM of Colloidal Nanocrystal Growth Using Graphene Liquid Cells ↗](https://doi.org/10.1126/science.1217654)**Jong Min Yuk, Jungwon Park, Peter A. Ercius et al.*1,153 citations*
78. **[Multiblock Polymers: Panacea or Pandora’s Box? ↗](https://doi.org/10.1126/science.1215368)**Frank S. Bates, Marc A. Hillmyer, Timothy P. Lodge et al.*1,142 citations*
79. **[Direction-Specific Interactions Control Crystal Growth by Oriented Attachment ↗](https://doi.org/10.1126/science.1219643)**Dongsheng Li, Michael H. Nielsen, Jonathan R. I. Lee et al.*1,120 citations*
80. **[Long-Range Incommensurate Charge Fluctuations in (Y,Nd)Ba 2 Cu 3 O 6+ x ↗](https://doi.org/10.1126/science.1223532)**Giacomo Claudio Ghiringhelli, M. Le Tacon, M. Minola et al.*1,113 citations*
81. **[Printing and Prototyping of Tissues and Scaffolds ↗](https://doi.org/10.1126/science.1226340)**Brian Derby*1,108 citations*
82. **[Predictive Self-Assembly of Polyhedra into Complex Structures ↗](https://doi.org/10.1126/science.1220869)**Pablo F. Damasceno, Michael Engel, Sharon C. Glotzer*1,095 citations*
83. **[Superconducting Dome in a Gate-Tuned Band Insulator ↗](https://doi.org/10.1126/science.1228006)**J. T. Ye, Yijin Zhang, Ryosuke Akashi et al.*1,088 citations*
84. **[Compartmentalized Control of Skin Immunity by Resident Commensals ↗](https://doi.org/10.1126/science.1225152)**Shruti Naik, Nicolas Jean Bouladoux, Christoph Wilhelm et al.*1,087 citations*
85. **[Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis ↗](https://doi.org/10.1126/science.1221789)**Iliyan Dimitrov Iliev, Vincent Anthony Funari, Kent D. Taylor et al.*1,072 citations*
86. **[Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas ↗](https://doi.org/10.1126/science.1224676)**Arnout G. Schepers, Hugo J.G. Snippert, Daniel E. Stange et al.*1,072 citations*
87. **[Ocean Salinities Reveal Strong Global Water Cycle Intensification During 1950 to 2000 ↗](https://doi.org/10.1126/science.1212222)**Paul J. Durack, Susan Wijffels, Richard J. Matear*1,067 citations*
88. **[Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation ↗](https://doi.org/10.1126/science.1223560)**Amrita M. Nargund, Mark W. Pellegrino, Christopher J. Fiorese et al.*1,059 citations*
89. **[The Evolutionary Landscape of Alternative Splicing in Vertebrate Species ↗](https://doi.org/10.1126/science.1230612)**Nuno L. Barbosa‐Morais, Manuel Irimia, Qun Pan et al.*1,059 citations*
90. **[The Geological Record of Ocean Acidification ↗](https://doi.org/10.1126/science.1208277)**Bärbel Hönisch, Andy J. Ridgwell, Daniela N. Schmidt et al.*1,056 citations*
91. **[Relaxation and Prethermalization in an Isolated Quantum System ↗](https://doi.org/10.1126/science.1224953)**Michael Gring, Maximilian Kuhnert, Tim Langen et al.*1,047 citations*
92. **[ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models ↗](https://doi.org/10.1126/science.1217697)**Paige E. Cramer, John R. Cirrito, Daniel W. Wesson et al.*1,045 citations*
93. **[Identifying Influential and Susceptible Members of Social Networks ↗](https://doi.org/10.1126/science.1215842)**Sinan Aral, Dylan Walker*1,042 citations*
94. **[Exceptional Activity for Methane Combustion over Modular Pd@CeO 2 Subunits on Functionalized Al 2 O 3 ↗](https://doi.org/10.1126/science.1222887)**Matteo Cargnello, J. J. Delgado Jaén, Juan Carlos Hernández‐Garrido et al.*1,023 citations*
95. **[The Pulvinar Regulates Information Transmission Between Cortical Areas Based on Attention Demands ↗](https://doi.org/10.1126/science.1223082)**Yuri B. Saalmann, Mark A. Pinsk, Liang Wang et al.*1,013 citations*
96. **[Quantifying the Impact of Human Mobility on Malaria ↗](https://doi.org/10.1126/science.1223467)**Amy Wesolowski, Nathan Eagle, Andrew J. Tatem et al.*989 citations*
97. **[The Crust of the Moon as Seen by GRAIL ↗](https://doi.org/10.1126/science.1231530)**Mark A. Wieczorek, Gregory A. Neumann, F. Nimmo et al.*976 citations*
98. **[Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues ↗](https://doi.org/10.1126/science.1228186)**Jason J. Merkin, Caitlin R. Russell, Ping Chen et al.*968 citations*
99. **[Recent Plant Diversity Changes on Europe’s Mountain Summits ↗](https://doi.org/10.1126/science.1219033)**Harald Pauli, Michael Gottfried, Stefan Dullinger et al.*962 citations*
100. **[Graphene Barristor, a Triode Device with a Gate-Controlled Schottky Barrier ↗](https://doi.org/10.1126/science.1220527)**Heejun Yang, Jinseong Heo, Seongjun Park et al.*961 citations*

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