---
title: "Science 2022 — all accepted papers, page 4 — the most cited first"
description: "All 2,047 papers of Science 2022 · page 4 of 21, the most cited first; those with our summary link to it."
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# Science 2022: all accepted papers

2,047 papers · page 4 of 21 · the most cited first · [← Science 2022](https://md.research.elamur.ai/free/en/venues/science/2022/)

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301. **[Intensifying existing urban wastewater ↗](https://doi.org/10.1126/science.abm3900)**Mari K.H. Winkler, Mark C.M. van Loosdrecht*173 citations*
302. **[The effects of oral microbiota on health ↗](https://doi.org/10.1126/science.abn1890)**Timur Tuganbaev, Koji Yoshida, Kenya Honda*173 citations*
303. **[COVID mortality in India: National survey data and health facility deaths ↗](https://doi.org/10.1126/science.abm5154)**Prabhat Jha, Yashwant Deshmukh, Chinmay Tumbe et al.*172 citations*
304. **[Multidimensional control of therapeutic human cell function with synthetic gene circuits ↗](https://doi.org/10.1126/science.ade0156)**Hui-Shan Li, Divya V. Israni, Keith A. Gagnon et al.*172 citations*
305. **[Pebbles and sand on asteroid (162,173) Ryugu: In situ observation and particles returned to Earth ↗](https://doi.org/10.1126/science.abj8624)**Shogo Tachibana, Hirotaka Sawada, Ryuji Okazaki et al.*172 citations*
306. **[Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment ↗](https://doi.org/10.1126/science.abq4835)**Shiya Cheng, Gerrit Altmeppen, Chun So et al.*171 citations*
307. **[ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome ↗](https://doi.org/10.1126/science.abl6324)**Kim S. Robinson, Gee Ann Toh, Pritisha Rozario et al.*171 citations*
308. **[Polarized x-rays constrain the disk-jet geometry in the black hole x-ray binary Cygnus X-1 ↗](https://doi.org/10.1126/science.add5399)**Henric S. Krawczynski, Fabio Muleri, Michal Dovčiak et al.*170 citations*
309. **[Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529 ↗](https://doi.org/10.1126/science.abn8897)**Tongqing Zhou, Lingshu Wang, John Misasi et al.*170 citations*
310. **[A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin ↗](https://doi.org/10.1126/science.abq0132)**Qiyao Chai, Shanshan Yu, Yanzhao Zhong et al.*169 citations*
311. **[Blots on a field? ↗](https://doi.org/10.1126/science.add9993)**Charles Piller*169 citations*
312. **[Tuning T cell receptor sensitivity through catch bond engineering ↗](https://doi.org/10.1126/science.abl5282)**Xiang Zhao, Elizabeth Motunrayo Kolawole, Waipan Chan et al.*169 citations*
313. **[ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies ↗](https://doi.org/10.1126/science.abq2679)**Jun Siong Low, Josipa Jerak, M. Alejandra Tortorici et al.*167 citations*
314. **[Accelerating reaction generality and mechanistic insight through additive mapping ↗](https://doi.org/10.1126/science.abn1885)**Cesar N. Prieto Kullmer, Jacob A. Kautzky, Shane W. Krska et al.*167 citations*
315. **[Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines ↗](https://doi.org/10.1126/science.abq0203)**John E. Bowen, Amin Addetia, Ha V. Dang et al.*166 citations*
316. **[Time-restricted feeding mitigates obesity through adipocyte thermogenesis ↗](https://doi.org/10.1126/science.abl8007)**Chelsea Hepler, Benjamin J. Weidemann, Nathan J. Waldeck et al.*165 citations*
317. **[Madagascar’s extraordinary biodiversity: Threats and opportunities ↗](https://doi.org/10.1126/science.adf1466)**Hélène Ralimanana, Allison Perrigo, Rhian J. Smith et al.*164 citations*
318. **[Z-DNA binding protein 1 promotes heatstroke-induced cell death ↗](https://doi.org/10.1126/science.abg5251)**Fangfang Yuan, Jizhen Cai, Jianfeng Wu et al.*164 citations*
319. **[Architecture of the cytoplasmic face of the nuclear pore ↗](https://doi.org/10.1126/science.abm9129)**Christopher J. Bley, Si Nie, George W. Mobbs et al.*163 citations*
320. **[Amplification of human interneuron progenitors promotes brain tumors and neurological defects ↗](https://doi.org/10.1126/science.abf5546)**Oliver L. Eichmüller, Nina S. Corsini, Ábel Vértesy et al.*161 citations*
321. **[Limited climate change mitigation potential through forestation of the vast dryland regions ↗](https://doi.org/10.1126/science.abm9684)**Shani Rohatyn, Dan Yakir, Eyal Rotenberg et al.*161 citations*
322. **[Single-step hydrogen production from NH3, CH4, and biogas in stacked proton ceramic reactors ↗](https://doi.org/10.1126/science.abj3951)**Daniel R. Clark, Harald Fjeld, Michael Budd et al.*160 citations*
323. **[Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1 ↗](https://doi.org/10.1126/science.abf8271)**Bridget S. Gosis, Shogo Wada, Chelsea L. Thorsheim et al.*159 citations*
324. **[Mastering the game of Stratego with model-free multiagent reinforcement learning ↗](https://doi.org/10.1126/science.add4679)**Julien Pérolat, Bart De Vylder, Daniel Hennes et al.*159 citations*
325. **[TaCol-B5 modifies spike architecture and enhances grain yield in wheat ↗](https://doi.org/10.1126/science.abm0717)**Xiaoyu Zhang, Haiyan Jia, Tian Li et al.*159 citations*
326. **[Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp 3 )−H azidation ↗](https://doi.org/10.1126/science.abj2830)**Jinyan Rui, Qun Zhao, Anthony J. Huls et al.*158 citations*
327. **[Few-cycle vacuum squeezing in nanophotonics ↗](https://doi.org/10.1126/science.abo6213)**Rajveer Nehra, Ryoto Sekine, Luis M. Ledezma et al.*158 citations*
328. **[Growth rules for irregular architected materials with programmable properties ↗](https://doi.org/10.1126/science.abn1459)**Ke Liu, Rachel Sun, Chiara Daraio*158 citations*
329. **[Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children ↗](https://doi.org/10.1126/science.abo3627)**Danyel Lee, Jérémie Le Pen, Ahmad Yatim et al.*158 citations*
330. **[Modular terpene synthesis enabled by mild electrochemical couplings ↗](https://doi.org/10.1126/science.abn1395)**Stephen J. Harwood, Maximilian D. Palkowitz, Cara N. Gannett et al.*158 citations*
331. **[Rewilding plant microbiomes ↗](https://doi.org/10.1126/science.abn6350)**Jos M. Raaijmakers, E. Toby Kiers*158 citations*
332. **[GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein ↗](https://doi.org/10.1126/science.abk0637)**Maria E. Diaz‐Ortiz, Yunji Seo, Marijan Posavi et al.*156 citations*
333. **[Madagascar’s extraordinary biodiversity: Evolution, distribution, and use ↗](https://doi.org/10.1126/science.abf0869)**Alexandre Antonelli, Rhian J. Smith, Allison Perrigo et al.*156 citations*
334. **[Moore’s law: The journey ahead ↗](https://doi.org/10.1126/science.ade2191)**Mark Lundstrom, Muhammad Ashraful Alam*156 citations*
335. **[Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis ↗](https://doi.org/10.1126/science.abn7565)**Vishwas G. Chandrashekhar, Wolfgang Baumann, Matthias Beller et al.*156 citations*
336. **[Visualizing Eigen/Zundel cations and their interconversion in monolayer water on metal surfaces ↗](https://doi.org/10.1126/science.abo0823)**Ye Tian, Jiani Hong, Duanyun Cao et al.*156 citations*
337. **[Carbene reactivity from alkyl and aryl aldehydes ↗](https://doi.org/10.1126/science.abo6443)**Lumin Zhang, Bethany M. DeMuynck, Alyson N. Paneque et al.*155 citations*
338. **[Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling ↗](https://doi.org/10.1126/science.adc8969)**Mohammad Kawsar Manik, Yun Yu Shi, Sulin Li et al.*155 citations*
339. **[Deracemization through photochemical E / Z isomerization of enamines ↗](https://doi.org/10.1126/science.abl4922)**Mouxin Huang, Long Zhang, Tianrun Pan et al.*155 citations*
340. **[Inefficient and unlit natural gas flares both emit large quantities of methane ↗](https://doi.org/10.1126/science.abq0385)**Genevieve Plant, Eric Adam Kort, Adam R. Brandt et al.*155 citations*
341. **[Zygotic genome activation by the totipotency pioneer factor Nr5a2 ↗](https://doi.org/10.1126/science.abn7478)**Johanna Gassler, Wataru Kobayashi, Imre Gáspár et al.*155 citations*
342. **[Simultaneous electrical and thermal rectification in a monolayer lateral heterojunction ↗](https://doi.org/10.1126/science.abq0883)**Yufeng Zhang, Qian Lv, Haidong Wang et al.*154 citations*
343. **[Termite sensitivity to temperature affects global wood decay rates ↗](https://doi.org/10.1126/science.abo3856)**Amy E. Zanne, Habacuc Flores‐Moreno, Jeff R. Powell et al.*154 citations*
344. **[Enhanced T cell effector activity by targeting the Mediator kinase module ↗](https://doi.org/10.1126/science.abn5647)**Katherine A. Freitas, Julia A. Belk, Elena Sotillo et al.*153 citations*
345. **[Liquid metal synthesis solvents for metallic crystals ↗](https://doi.org/10.1126/science.abm2731)**Shuhada A. Idrus‐Saidi, Jianbo Tang, Stephanie G. Lambie et al.*153 citations*
346. **[Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure ↗](https://doi.org/10.1126/science.abn0910)**Yang Cao, Yuchen Wang, Zhenqi Zhou et al.*153 citations*
347. **[Soft, bioresorbable coolers for reversible conduction block of peripheral nerves ↗](https://doi.org/10.1126/science.abl8532)**Jonathan T. Reeder, Zhaoqian Xie, Quansan Yang et al.*153 citations*
348. **[Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel ↗](https://doi.org/10.1126/science.abl4292)**Ottavia Prunas, Joshua L. Warren, Forrest W. Crawford et al.*153 citations*
349. **[The January 2022 eruption of Hunga Tonga-Hunga Ha’apai volcano reached the mesosphere ↗](https://doi.org/10.1126/science.abo4076)**Simon Proud, Andrew T. Prata, Simeon Schmauss*152 citations*
350. **[Ferroelectric crystals with giant electro-optic property enabling ultracompact Q-switches ↗](https://doi.org/10.1126/science.abn7711)**Xin Liu, Peng Tan, Xue Ma et al.*151 citations*
351. **[RALF peptide signaling controls the polytubey block in Arabidopsis ↗](https://doi.org/10.1126/science.abl4683)**Sheng Zhong, Ling Li, Ling Li et al.*151 citations*
352. **[Nanosecond protonic programmable resistors for analog deep learning ↗](https://doi.org/10.1126/science.abp8064)**Murat Onen, Nicolas Émond, Baoming Wang et al.*150 citations*
353. **[Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT ↗](https://doi.org/10.1126/science.abp9466)**Haruhiko Ehara, Tomoya Kujirai, Mikako Shirouzu et al.*150 citations*
354. **[Dilution-induced gel-sol-gel-sol transitions by competitive supramolecular pathways in water ↗](https://doi.org/10.1126/science.abn3438)**Lu Su, Jesús Mosquera, Mathijs F. J. Mabesoone et al.*149 citations*
355. **[MTCH2 is a mitochondrial outer membrane protein insertase ↗](https://doi.org/10.1126/science.add1856)**Alina Guna, Taylor A. Stevens, Alison J. Inglis et al.*149 citations*
356. **[Promotion of superconductivity in magic-angle graphene multilayers ↗](https://doi.org/10.1126/science.abn8585)**Yiran Zhang, Robert Polski, Cyprian Lewandowski et al.*149 citations*
357. **[Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor ↗](https://doi.org/10.1126/science.abn7065)**Elissa A. Fink, Jun Z. Xu, Harald Hübner et al.*149 citations*
358. **[Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria ↗](https://doi.org/10.1126/science.abk2066)**Rohan Balakrishnan, Matteo Mori, Igor Šegota et al.*148 citations*
359. **[The critically endangered vaquita is not doomed to extinction by inbreeding depression ↗](https://doi.org/10.1126/science.abm1742)**Jacqueline A. Robinson, Christopher C. Kyriazis, Sergio F. Nigenda‐Morales et al.*148 citations*
360. **[Three-dimensional nanofabrication via ultrafast laser patterning and kinetically regulated material assembly ↗](https://doi.org/10.1126/science.abm8420)**Fei Xue Han, Songyun Gu, Aleks Klimas et al.*147 citations*
361. **[A chromosomal inversion contributes to divergence in multiple traits between deer mouse ecotypes ↗](https://doi.org/10.1126/science.abg0718)**Emily Rickman Hager, Olivia S. Harringmeyer, T. Brock Wooldridge et al.*146 citations*
362. **[Remote steric control for undirected meta -selective C–H activation of arenes ↗](https://doi.org/10.1126/science.abm7599)**Ramadoss Boobalan, Yushu Jin, Sobi Asako et al.*146 citations*
363. **[Shared TIR enzymatic functions regulate cell death and immunity across the tree of life ↗](https://doi.org/10.1126/science.abo0001)**Kow Essuman, Jeffrey Milbrandt, Jeffery L. Dangl et al.*146 citations*
364. **[Trained ILC3 responses promote intestinal defense ↗](https://doi.org/10.1126/science.aaz8777)**Nicolas Serafini, Angélique Jarade, Laura Surace et al.*146 citations*
365. **[Mechanism of spindle pole organization and instability in human oocytes ↗](https://doi.org/10.1126/science.abj3944)**Chun So, Katerina Menelaou, Julia Uraji et al.*145 citations*
366. **[Cross-trait assortative mating is widespread and inflates genetic correlation estimates ↗](https://doi.org/10.1126/science.abo2059)**Richard Border, Georgios I. Athanasiadis, Alfonso Buil et al.*144 citations*
367. **[Tunable light-induced dipole-dipole interaction between optically levitated nanoparticles ↗](https://doi.org/10.1126/science.abp9941)**Jakob Rieser, Mario Arnolfo Ciampini, Henning Rudolph et al.*143 citations*
368. **[Models predict planned phosphorus load reduction will make Lake Erie more toxic ↗](https://doi.org/10.1126/science.abm6791)**Ferdi L. Hellweger, Robbie M. Martin, Falk Eigemann et al.*142 citations*
369. **[Optical absorption of interlayer excitons in transition-metal dichalcogenide heterostructures ↗](https://doi.org/10.1126/science.abm8511)**Elyse Barré, Ouri Karni, Erfu Liu et al.*142 citations*
370. **[Polytriazole membranes with ultrathin tunable selective layer for crude oil fractionation ↗](https://doi.org/10.1126/science.abm7686)**Ştefan Chişcă, Valentina Elena Musteata, Wen Zhang et al.*142 citations*
371. **[Synthetic multistability in mammalian cells ↗](https://doi.org/10.1126/science.abg9765)**Ronghui Zhu, Jesus M. del Rio-Salgado, Jordi García‐Ojalvo et al.*142 citations*
372. **[Cavity-mediated electron-photon pairs ↗](https://doi.org/10.1126/science.abo5037)**Armin Feist, Guanhao Huang, Germaine Arend et al.*141 citations*
373. **[Rapid increase in Omicron infections in England during December 2021: REACT-1 study ↗](https://doi.org/10.1126/science.abn8347)**Paul Elliott, Barbara Bodinier, Oliver D. Eales et al.*141 citations*
374. **[Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry ↗](https://doi.org/10.1126/science.abm8143)**Young‐Jun Park, Anna De Marco, Tyler N. Starr et al.*140 citations*
375. **[Orderly disorder in magic-angle twisted trilayer graphene ↗](https://doi.org/10.1126/science.abk1895)**Simon Turkel, Joshua Swann, Ziyan Zhu et al.*139 citations*
376. **[Water vapor injection into the stratosphere by Hunga Tonga-Hunga Ha’apai ↗](https://doi.org/10.1126/science.abq2299)**Holger Vömel, Stéphanie Evan, Matthew B. Tully*139 citations*
377. **[An olivine cumulate outcrop on the floor of Jezero crater, Mars ↗](https://doi.org/10.1126/science.abo2756)**Yang Liu, Michael M. Tice, M. E. Schmidt et al.*138 citations*
378. **[Conversion of oxybenzone sunscreen to phototoxic glucoside conjugates by sea anemones and corals ↗](https://doi.org/10.1126/science.abn2600)**Djordje Vuckovic, Amanda I. Tinoco, Lorraine Ling et al.*138 citations*
379. **[The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells ↗](https://doi.org/10.1126/science.aaz5284)**Rafael Donadelli Melani, Vincent R. Gerbasi, Lissa C. Anderson et al.*138 citations*
380. **[ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack ↗](https://doi.org/10.1126/science.abl3855)**Alex T. Ritter, Gleb E. Shtengel, C. Shan Xu et al.*137 citations*
381. **[Frequency-dependent polarization of repeating fast radio bursts—implications for their origin ↗](https://doi.org/10.1126/science.abl7759)**Yi Feng, Di Li, Yuan-Pei Yang et al.*137 citations*
382. **[In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains ↗](https://doi.org/10.1126/science.abm6704)**Hugo van den Hoek, Nikolai Klena, Mareike A. Jordan et al.*137 citations*
383. **[Self-assembly of nanocrystals into strongly electronically coupled all-inorganic supercrystals ↗](https://doi.org/10.1126/science.abm6753)**Igor Coropceanu, Eric M. Janke, Joshua Portner et al.*137 citations*
384. **[Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution ↗](https://doi.org/10.1126/science.abe7489)**Yimeng Kong, Lei Cao, Gintaras Y. Deikus et al.*136 citations*
385. **[Visualizing broken symmetry and topological defects in a quantum Hall ferromagnet ↗](https://doi.org/10.1126/science.abm3770)**Xiaomeng Liu, Gelareh Farahi, Cheng-Li Chiu et al.*136 citations*
386. **[Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning ↗](https://doi.org/10.1126/science.abq0225)**Kyle G. Daniels, Shangying Wang, Milos Simic et al.*135 citations*
387. **[Inhibiting creep in nanograined alloys with stable grain boundary networks ↗](https://doi.org/10.1126/science.abq7739)**B. B. Zhang, Yingguang Tang, Qingsong Mei et al.*134 citations*
388. **[TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets ↗](https://doi.org/10.1126/science.abj8695)**Bernardo Sgarbi Reis, Patrick W. Darcy, Iasha Z. Khan et al.*134 citations*
389. **[Halogen-atom and group transfer reactivity enabled by hydrogen tunneling ↗](https://doi.org/10.1126/science.abq8663)**Timothée Constantin, Bartosz Górski, Michael J. Tilby et al.*133 citations*
390. **[Multimodal perception links cellular state to decision-making in single cells ↗](https://doi.org/10.1126/science.abf4062)**Bernhard A. Kramer, Jacobo Sarabia del Castillo, Lucas Pelkmans*133 citations*
391. **[Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device ↗](https://doi.org/10.1126/science.abo7651)**Brian D. Reed, Michael J. Meyer, Valentin Abramzon et al.*133 citations*
392. **[Structural basis for strychnine activation of human bitter taste receptor TAS2R46 ↗](https://doi.org/10.1126/science.abo1633)**Weixiu Xu, Lijie Wu, Shenhui Liu et al.*133 citations*
393. **[Defining the onset of the Anthropocene ↗](https://doi.org/10.1126/science.ade2310)**Colin N. Waters, Simon Turner*132 citations*
394. **[Allylic C–H amination cross-coupling furnishes tertiary amines by electrophilic metal catalysis ↗](https://doi.org/10.1126/science.abn8382)**Siraj Z. Ali, Brenna G. Budaitis, Devon F.A. Fontaine et al.*131 citations*
395. **[Climate change drives rapid decadal acidification in the Arctic Ocean from 1994 to 2020 ↗](https://doi.org/10.1126/science.abo0383)**Di Qi, Zhangxian Ouyang, Liqi Chen et al.*131 citations*
396. **[Enantioselective hydrogen-bond-donor catalysis to access diverse stereogenic-at-P(V) compounds ↗](https://doi.org/10.1126/science.abp8488)**Katherine C. Forbes, Eric N. Jacobsen*131 citations*
397. **[Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants ↗](https://doi.org/10.1126/science.abm0811)**Catherine J. Reynolds, Joseph M. Gibbons, Corinna Pade et al.*131 citations*
398. **[Moving fast makes for better cooling ↗](https://doi.org/10.1126/science.ade9645)**Bingchao Qin, Li‐Dong Zhao*131 citations*
399. **[Recreating the heart’s helical structure-function relationship with focused rotary jet spinning ↗](https://doi.org/10.1126/science.abl6395)**Huibin Chang, Qihan Liu, John F. Zimmerman et al.*131 citations*
400. **[Soft strain-insensitive bioelectronics featuring brittle materials ↗](https://doi.org/10.1126/science.abn5142)**Yichao Zhao, Bo Wang, Jiawei Tan et al.*131 citations*

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